肺水通道蛋白与肺内液体平衡  

Aquaporin in lung and lung fluid balance

作　　者：吕钦 杨堃[1] Lyu Qin;Yang Kun(Department of Anesthesiology,the First Affiliated Hospital of Kunming Medical University,Kunming 650032,China)

机构地区：[1]昆明医科大学第一附属医院麻醉科,650032

出　　处：《国际麻醉学与复苏杂志》2021年第5期553-556,共4页International Journal of Anesthesiology and Resuscitation

基　　金：国家自然科学基金(81560320);云南省高层次卫生计生技术人才培养基金(H-201647)。

摘　　要：水通道蛋白(aquaporin,AQP)是一类对水分子有高度特异性的转运膜蛋白,其对水分子的主动转运功能是维持细胞内外液体平衡的关键因素。在人体各个器官组织中,AQP的表达类型和程度各不相同,肺组织中主要有AQP1、AQP4、AQP5的参与。由于多种因素会影响AQP的表达,引发肺内液体失衡,因此文章阐述了AQP在肺组织中维持液体平衡的作用及参与肺损伤形成的相关机制,进一步结合临床探究多种调节因素作用下AQP的表达情况及对机体的影响。Aquaporins(AQP)are transport membrane proteins with high specificity for water molecules.Their active transport function for water molecules is the key factor to maintain the liquid balance inside and outside cells.The type and extent of AQP expression varies in various human organ tissues,with predominant involvement of AQP1,AQP4,and AQP5 in lung tissue.Because many factors can affect the expression of AQP and lead to fluid imbalance in the lung,this paper illustrates its role in maintaining fluid balance in the lung tissue and the related mechanisms involved in the formation of lung injury,further combined with clinical exploration of the expression of AQPs and the effect on the body of multiple regulatory factors.

关 键 词：水通道蛋白 肺 右美托咪定 

分 类 号：R563[医药卫生—呼吸系统]