五子衍宗丸加减联合西药对排卵障碍性不孕患者的促孕效果  

Study on the Effects of Modified Wuzi Yanzong Pills Combined with Western Medicine in the Treatment of Patients with Anovulatory Infertility

作　　者：何金群 刘凤萍 黄亚玲 邓丽娟 黄莉华 HE Jinqun;LIU Fengping;HUANG Yaling;DENG Lijuan;HUANG Lihua(Department of Obstetrics and Gynecology,Qingyuan Traditional Chinese Medicine Hospital of Guangdong Province,Qingyuan 511500,China;Department of Obstetrics and Gynecology,Heyuan Traditional Chinese Medicine Hospital of Guangdong Province,Heyuan 517000,China;Qingcheng District People′s Hospital of Guangdong Province,Qingyuan 511500,China)

机构地区：[1]广东省清远市中医院妇产科,清远511500 [2]广东省河源市中医院妇产科,河源517000 [3]广东省清远市清城区人民医院,清远511500

出　　处：《世界中医药》2021年第9期1463-1467,共5页World Chinese Medicine

基　　金：广东省中医药局科研项目(20182186)。

摘　　要：目的:探讨五子衍宗丸加减联合西药对排卵障碍性不孕患者的促孕效果。方法:选取2018年6月至2020年6月清远市中医院收治的排卵障碍性不孕患者90例作为研究对象,按照随机数字表法分为西药组、中药组和联合组,每组30例。西药组给予枸橼酸氯米芬胶囊治疗,中药组给予五子衍宗丸加减治疗,联合组给予以上2种方法联合治疗,比较3组有效率、子宫内膜以及排卵率等指标。结果:治疗后,联合组、中药组、西药组的总有效率分别为93.33%、66.67%、73.33%,3组有效率差异有统计学意义(P<0.05)。联合组和中药组治疗后子宫内膜明显增厚(P<0.05)。联合组、中药组、西药组的周期排卵率分别为74.05%、49.65%、62.16%,3组排卵率差异有统计学意义(P<0.05)。治疗后联合组的基础体温(BBT)分布双相患者例数增加、妊娠率升高、宫颈黏液评分(CMS)提高,且优于中药组和西药组,差异有统计学意义(P<0.05)。结论:五子衍宗丸加减联合西药枸橼酸氯米芬胶囊可以改善排卵障碍性不孕患者的排卵率、妊娠率、子宫内膜厚度、BBT分布以及CMS,并且评分疗效较单独使用中药或者单独使用西药好。Objective:To study the effect of Wuzi Yanzong Pills combined with Western medicine in the treatment of patients with anovulatory infertility.Methods:A total of 90 patients with anovulatory infertility admitted to Qingyuan Traditional Chinese Medicine Hospital from January 2019 to January 2020 were selected as the research objects and were randomly divided into a Western medicine group,a traditional Chinese medicine group and a combined group,with 30 cases in each group.Patients in the Western medicine group were treated with clomiphene citrate capsule,and patients in the traditional Chinese medicine group were treated with Wuzi Yanzong Pills,and patients in the combined group were treated with both methods above.The efficiency,endometrium and ovulation rate were compared among in the 3 groups.Results:After treatment,the total effective rates of combined group,traditional Chinese medicine group and Western medicine group were 93.33%,66.67%and 73.33%respectively.There was significant difference among 3 groups(P<0.05).The endometrium in the combined group and the traditional Chinese medicine group was obviously thickened(P<0.05).The periodic ovulation rates of combined group,Chinese medicine group and Western medicine group were 74.05%,49.65%and 62.16%respectively.There was a statistically significant difference in ovulation rate among the 3 groups(P<0.05).After treatment,BBT scores of biphasic patients in the combined group increased,pregnancy rate increased,CMS scores increased.Those were better than those in the traditional Chinese medicine group and Western medicine group,and the difference was statistically significant(P<0.05).Conclusion:Wuzi Yanzong Pills combined with clomiphene citrate capsule can significantly improve ovulation rate,pregnancy rate,endometrial thickness,BBT distribution and CMS of anovulatory infertility patients,and the distribution is better than that of traditional Chinese medicine only or Western medicine only.

关 键 词：五子衍宗丸 枸橼酸氯米芬胶囊 排卵障碍性不孕 促孕效果 子宫内膜 排卵率 体温 妊娠 

分 类 号：R289.5[医药卫生—方剂学] R711.5[医药卫生—中药学]