河北汉族人群ABO血型与高血压关联性  

Association of ABO blood group with hypertension among Han population in Hebei province

作　　者：高江铃 崔泽[2] 潘利[1] 孙纪新[2] 张佳 曹亚景[2] 王也 余程东 刘倩倩 张玲 何慧婧[1] 单广良[1] GAO Jiang-ling;CUI Ze;PAN Li(Department of Epidemiology and Health Statistics,Institute of Basic Medical Sciences,Chinese Academy of Medical Sciences,School of Basic Medicine,Peking Union Medical College,Beijing 100005,China;不详)

机构地区：[1]中国医学科学院基础医学研究所,北京协和医学院基础学院流行病与卫生统计学系,北京100005 [2]河北省疾病预防控制中心 [3]首都医科大学公共卫生学院流行病与卫生统计学系

出　　处：《中国公共卫生》2021年第5期803-806,共4页Chinese Journal of Public Health

基　　金：国家重点研发计划(2016YFC0900601);中国医学科学院医学与健康科技创新工程(2016–I2M–2–004;2019–I2M–2–007)。

摘　　要：目的了解河北省20~80岁汉族人群高血压患病现状,探讨ABO血型与高血压之间的关系。方法2017年7—8月对河北省汉族居民进行横断面调查,采用多阶段分层整群抽样方法,招募调查对象并进行面对面问卷调查、体格检查和ABO血型检测。体格检查包括血压测量和身高体重测量,所有研究对象按标准流程检测ABO血型,以2010年全国普查河北省人口数据作为参照,使用直接标化法计算标化患病率;采用协方差比较不同血型的血压值;采用非条件logistic回归模型探讨ABO血型和高血压的关联性。结果本研究共纳入3828名20~80岁汉族常住居民,其中男性1616人(42.2%),女性2212人(57.8%),高血压粗患病率为39.8%,年龄性别标化患病率为34.1%(男性:39.9%,女性:28.1%)。不同血型高血压患病率分别为O型40.0%(450/1126),A型40.0%(372/929),B型39.0%(535/1371),AB型41.8%(168/402)。协方差分析结果显示,校正年龄、性别、城乡、体质指数(BMI)、教育程度、吸烟、饮酒、体力活动和家族史后,不同ABO血型人群血压值差异无统计学意义(P>0.05);多因素非条件logistic回归分析结果显示,在调整年龄、性别、城乡、BMI、吸烟、饮酒、家族史等因素后,ABO血型与高血压无统计学关联。结论河北省汉族人群高血压患病率存在性别和城乡差异;ABO血型与高血压无关联性。Objective To examine the prevalence of hypertension in Han people aged 20–80 living in Hebei province and to explore the association between ABO blood group and hypertension.Methods A cross-sectional study was conducted in Hebei province from July to August 2017.The study sites were selected using multistage stratified cluster sampling.All participants underwent face-to-face questionnaire interview,physical examination and ABO blood group testing;the physical examination included blood pressure measurement and height-weight measurement.ABO blood group was tested by standard procedures.Using demographic data of Hebei province from the 2010 national census as the reference,the standardized prevalence was calculated with direct standardization method.Blood pressure values of different blood groups were compared by covariance analysis.Logistic regression models were used to analyze the association between ABO blood group and hypertension.Results A total of 3828 permanent Han residents aged 20–80 years were included in this study;of which,1616(42.2%)were men and 2212(57.8%)were women.The crude prevalence of hypertension was 39.8%;the age-and gender-standardized prevalence of hypertension was 34.1%(male:39.9%,female:28.1%).The prevalence of hypertension was the highest(41.8%,168/402)in the residents with blood group AB,followed by that in the residents with O(40.0%,450/1126),A(40.0%,372/929),and B(39.0%,535/1371).Covariance analysis revealed no significant difference in blood pressure values among the residents with different blood groups after adjusting for age,sex,living region(urban or rural),body mass index(BMI),education,smoking,alcohol drinking,physical activity,and family hypertension history(P>0.05 for all).Multivariate logistic regression analysis demonstrated that there was no statistical significant association between ABO blood group and hypertension after adjusting for age,gender,living region,BMI,smoking,alcohol drinking,and family hypertension history.Conclusion There are gender and urban-rural diffe

关 键 词：河北省 高血压 患病率 ABO血型 

分 类 号：R544.1[医药卫生—心血管疾病]