α-(1,2-亚乙基)酰胺与端炔[4+1]合成螺环吡咯啉-2-酮  

[4+1]Annulation ofα-(1,2-ethylene)Amides and Terminal Alkynes to Access Spirocyclic Pyrroline-2-one

作　　者：任传清[1] 季晓晖[1] 季建伟[1] 张强[1] 宋娟[1] REN Chuan-qing;JI Xiao-hui;JI Jian-wei;ZHANG Qiang;SONG Juan(Shaanxi Key laboratory of Catalysis, School of Chemical & Environmental Science, Shaanxi University of Technology, Hanzhong 723000, China)

机构地区：[1]陕西理工大学化学与环境科学学院催化基础与应用重点实验室,陕西汉中723000

出　　处：《合成化学》2021年第5期430-434,共5页Chinese Journal of Synthetic Chemistry

基　　金：陕西省科技厅自然科学基础研究计划项目(2020JM-602);陕西省教育厅基金资助项目(19JS011);陕西理工大学人才启动项目(SLGKYQD2-12)。

摘　　要：以α-(1,2-亚乙基)酰胺和端炔发生[4+1]环合反应,高效合成了一系列螺环类吡咯啉-2-酮类化合物,其结构经^(1)H NMR,^(13)C NMR和HR-MS(ESI)表征,并对该反应机理进行了探讨。该合成方法具有底物适用范围广泛,操作简单,条件温和以及收率高等优点。A series of spirocyclic pyrroline-2-one compounds were obtained via[4+1]annulation ofα-(1,2-ethylene)amides and terminal alkynes,and the structures of target compounds were characterized by ^(1)H NMR,^(13)C NMR and HR-MS(ESI).Moreover,a mechanism for the reaction was proposed.The synthetic method has the advantages of extensive substrates,simple operation,mild conditions and high yield.

关 键 词：螺杂环化合物 [4+1]环化反应 端炔 合成 环加成 

分 类 号：O626.2[理学—有机化学]