手性金属配合物应用于不对称Henry反应研究进展  

Research Progress on Chiral Metal-catalyzed for Asymmetric Henry Reaction

作　　者：张瑶瑶 韩彪 李楠 宋雪婷 赵梦鸽 李博解 朱磊 ZHANG Yao-yao;HAN Biao;LI Nan;SONG Xue-ting;ZHAO Meng-ge;LI Bo-jie;ZHU Lei(School of Chemistry and Materials Science, Hubei Engineering University, Xiaogan 432000, China;School of Materials Science and Engineering, Hubei University, Wuhan 430062, China;Hubei Key Laboratory of Bioinorganic Chemistry & Materia Medica, Huazhong University of Science and Technology, Wuhan 430074, China)

机构地区：[1]湖北工程学院化学与材料科学学院,湖北孝感432000 [2]湖北大学材料科学与工程学院,湖北武汉430062 [3]华中科技大学生物无机化学与药物湖北省重点实验室,湖北武汉430074

出　　处：《合成化学》2021年第5期445-458,共14页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(21774029);湖北省自然科学基金资助项目(2019CFB237);湖北省高等学校优秀中青年科技创新团队计划项目(T201816);孝感市自然科学基金资助项目(XGKJ2020010041)。

摘　　要：手性β-硝基醇化合物是一类用途广泛的双官能团化合物,不对称Henry加成反应是制备手性β-硝基醇化合物最有效的方法之一,同时该反应在构建碳-碳键的过程中具有优异的原子经济性。在不对称Henry加成反应中,手性催化剂起到至关重要的作用,近年来围绕这一课题取得了许多重要进展。本文将从手性金属配合物中的铜配合物、锌配合物、稀土金属配合物、锰配合物以及钴配合物等多方面综述金属配位型催化剂在不对称催化Henry反应中的研究进展,并对其未来的发展前景进行了展望。Chiralβ-nitroalcohols are a class of bifunctional compounds with a wide range of applications.Asymmetric Henry addition reaction is considered as one of the most effective method to prepare chiralβ-nitroalcohols.On the other hand,the reaction has excellent atomic economy in the construction of C—C bonds.Chiral catalysts play an important role in asymmetric Henry addition reactions,and many important advances have been made in recent years.In this review,the recent advances of chiral metal complex in asymmetric Henry reaction to prepare chiralβ-nitroalcohols were mainly summarized from copper,zinc,rare earth,manganese and cobalt complexes of chiral metal complexes,and the future research direction is expected.

关 键 词：手性β-硝基醇 不对称Henry加成反应 手性金属配合物 综述 展望 

分 类 号：TQ460.1[化学工程—制药化工]