血清CXCL-12、CXCR-4和CXCR-7联合检测在诊断子宫腺肌病中的临床价值  

Clinical value of serum CXCL-12,CXCR-4 and CXCR-7 in the diagnosis of adenomyosis

作　　者：单君 李莉 SHAN Jun;LI Li(Department of Gynecology,Obstetrics and Gynecology Hospital,Fudan University,Shanghai 200090,China)

机构地区：[1]复旦大学附属妇产科医院妇科,上海200090

出　　处：《检验医学与临床》2021年第12期1673-1676,1680,共5页Laboratory Medicine and Clinic

摘　　要：目的探讨血清趋化因子配体(CXCL)-12、趋化因子受体(CXCR)-4和CXCR-7联合检测在诊断子宫腺肌病中的临床价值。方法选取2018年1月至2020年1月在该院就诊且病理确诊为子宫腺肌病的96例患者作为子宫腺肌病组,选取同期在该院诊治的子宫肌瘤75例患者和体检健康者45例分别作为子宫肌瘤组和健康对照组。观察各组血清CXCL-12、CXCR-4、CXCR-7和糖类抗原125(CA125)水平变化,血清CXCL-12、CXCR-4和CXCR-7水平对子宫腺肌病的诊断效能及其与病理分级、痛经程度和各指标之间的相互关系。结果子宫腺肌病组血清CXCL-12、CXCR-4和CA125水平明显高于子宫肌瘤组和健康对照组,而血清CXCR-7水平明显低于子宫肌瘤组和健康对照组,差异均有统计学意义(P<0.05);子宫肌瘤组血清CXCL-12、CXCR-4和CA125水平高于健康对照组,而血清CXCR-7水平明显低于健康对照组,差异均有统计学意义(P<0.05)。CXCL-12+CXCR-4+CXCR-7联合检测的灵敏度为85.4%,特异度为96.0%,受试者工作特征曲线下面积为0.953,明显高于单个指标CXCL-12(Z=4.221,P<0.001)、CXCR-4(Z=4.595,P<0.001)和CXCR-7(Z=4.628,P<0.001)。子宫腺肌病患者血清CXCL-12和CXCR-4水平与CXCR-7呈负相关(r=-0.682、-0.816,P<0.01),而血清CXCL-12水平与CXCR-4呈正相关(r=0.742,P<0.01)。结论血清CXCL-12、CXCR-4和CXCR-7水平与子宫腺肌病的严重程度具有密切关系,联合检测在诊断子宫腺肌病方面具有较高的灵敏度和特异度。Objective To investigate the clinical value of serum chemokine ligand(CXCL)-12,chemokine receptor(CXCR)-4 and CXCR-7 combined detection in the diagnosis of adenomyosis.Methods From January 2018 to January 2020,96 cases of adenomyosis were diagnosed pathologically in a hospital,which belonged to the adenomyosis group;75 cases of uterine fibroids diagnosed and treated in a hospital during the same period and 45 cases of healthy physical examination were uterine fibroids group and healthy control group,respectively.The serum CXCL-12,CXCR-4,CXCR-7,and carbohydrate antigen 125(CA125)levels were observed in each group.The serum CXCL-12,CXCR-4,and CXCR-7 levels in the diagnosis of adenomyosis,its correlation with pathological classification,severity dysmenorrhea and among each indicator were also observed.Results Serum CXCL-12,CXCR-4 and CA125 levels in adenomyosis group were significantly higher than those in uterine fibroid group and healthy control group,while serum CXCR-7 levels were significantly lower than those in uterine fibroid group and healthy control group,with statistical significance(P<0.05).The levels of CXCL-12,CXCR-4 and CA125 in uterine fibroids group were higher than those in healthy control group,while the level of CXCR-7 in uterine fibroids group was significantly lower than those in healthy control group,with statistical significance(P<0.05).The sensitivity and specificity of CXCL-12+CXCR-4+CXCR-7 combined detection were 85.4%,96.0%,and the area under the receiver operating characteristic curve was 0.953,which were significantly higher than those of CXCL-12(Z=4.221,P<0.001),CXCR-4(Z=4.595,P<0.001)and CXCR-7(Z=4.628,P<0.001).Serum CXCL-12 and CXCR-4 levels in adenomyosis patients were negatively correlated with CXCR-7(r=-0.682,-0.816,P<0.01),while serum CXCL-12 level was positively correlated with CXCR-4(r=0.742,P<0.01).Conclusion The serum CXCL-12,CXCR-4 and CXCR-7 levels are closely related to the severity of adenomyosis.Combined detection has high sensitivity and specificity in the diagnosis of a

关 键 词：趋化因子配体-12 趋化因子受体 子宫腺肌病 痛经 

分 类 号：R711.71[医药卫生—妇产科学]