辐照后硅掺杂羟基磷灰石顺磁性变化及其剂量学性能初步研究  

Paramagnetic changes and dosimetric characteristics of irradiated silicon-doped hydroxyapatite

作　　者：毕晓光 马蕾 郭俊旺 刘晔 纪云龙 耿爽 陈肖华 吴可 BI Xiao-guang;MA Lei;GUO Jun-wang;LIU Ye;JI Yun-long;GENG Shuang;CHEN Xiao-hua;WU Ke(Beijing Key Laboratory of Radiation Biology(No.BZ0325),Institute of Radiation Medicine,Academy of Military Medical Sciences,Academy of Military Sciences,Beijing 100850,China)

机构地区：[1]军事科学院军事医学研究院辐射医学研究所北京放射生物学重点实验室(No.BZ0325),北京100850

出　　处：《军事医学》2021年第4期272-277,共6页Military Medical Sciences

基　　金：国家自然科学基金(11905293,31670862);重点科研项目(BWS18J008,JK20191A060418);军事医学研究院基金项目(JK2019A020181)。

摘　　要：目的通过分析辐照后硅掺杂羟基磷灰石(Si-HAP)的顺磁性变化,研究Si-HAP材料的剂量学特性,为新型电离辐射剂量测量材料研究提供参考。方法采用化学沉淀法合成Si-HAP样品,利用不同光子能量射线源照射,采用电子自旋共振(ESR)波谱技术分析辐射相关信号的变化。结果合成的样品为Si-HAP,硅元素以Si-O基团形式嵌入在羟基磷灰石(HAP)晶格中;辐照后样品产生多种顺磁性中心并对应多重ESR波谱成分,以两种主要ESR信号(S3和S4)变化为评价指标,在0~100 Gy范围内剂量响应呈线性(R=0.9999),剂量检测下限分别为0.8 Gy(S3)、0.3 Gy(S4);在67.45~621.07 cGy/min剂量率范围内,S3无明显剂量率依赖性(F=0.250,P>0.05),S4在低剂量率点响应偏低(F=6.525,P<0.05);S3在30 d内衰减约10%并趋于稳定,S4衰减约40%;辐射诱发信号响应在光子能量较高时变化不明显,光子能量降低时敏感度升高。结论辐照后Si-HAP具有明确的辐照敏感性和剂量相关性,具有进一步深入探索的价值和应用于电离辐射剂量测量方面的潜力。Objective To study the dosimetry characteristics of irradiated silicon-doped hydroxyapatite(Si-HAP)materials by analyzing the paramagnetic changes in Si-HAP in order to provide reference for research on new materials for ionizing radiation dosimeter.Methods The Si-HAP sample was synthesized by chemical precipitation method and irradiated by radiation sources with different photon energy.Electron spin resonance(ESR) spectroscopy technology was used to analyze the changes in radiation-related signals.Results The synthesized sample was Si-HAP,and the silicon element was embedded in the hydroxyapatite(HAP) lattice in the form of Si-O groups.The irradiated sample produced multiple paramagnetic centers corresponding to multiple ESR spectrum components and two main ESR signals(S3 and S4) were used as evaluation indicators.The ESR signal increased linearly with the radiation dose in the investigated dose range of 0-100 Gy(R=0.9999) and the detection limit was 0.8 Gy and 0.3 Gy respectively.There was no significant dose rate dependence of S3(F=0.250,P>0.05)in the dose rate range of 67.45-621.07 cGy/min,but there was lower response of S4 at a low dose rate(F=6.525,P<0.05).Within 30 days,S3 signal was attenuated by 10% and then intended towards stability,while S4 was attenuated by 40%.The response of radiation-induced signals did not vary significantly in high photon energy areas,but increased when the photon energy was lower.Conclusion Si-HAP is definitely radiation sensitive and the dosimetry properties of Si-HAP suggest its value of further exploration and potential application in the dosimetry of ionizing radiation.

关 键 词：硅掺杂 羟基磷灰石类 顺磁性 辐射 剂量学 电子自旋共振 

分 类 号：R144.1[医药卫生—公共卫生与预防医学]