Daphnane-type diterpenes from genus Daphne and their anti-tumor activity  

作　　者：Zi-lin Hou Guo-dong Yao Shao-jiang Song 

机构地区：[1]Liaoning Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research&Development,School of Traditional Chinese Materia Medica,Shenyang Pharmaceutical University,Shenyang 110016,China

出　　处：《Chinese Herbal Medicines》2021年第2期145-156,共12页中草药（英文版）

基　　金：financially supported by National Nature Science Foundation of China[Grant No.81573319, 81872766, 81973528];China Postdoctoral Science Foundation[Grant No.2019M661135, 2017M620104]。

摘　　要：Daphnane-type diterpenenoids are the major biologically active constituents in the genus Daphne.We find that there are about 101 Daphnane-type diterpenes in this genus,most of those compounds show different degrees of inhibitory effect on various cancer cell.Some of them have been studied in depth and the potent molecular mechanisms might be associated with modulation of different cell-signaling pathways.In addition,some compounds of this type also can inhibit the synthesis of protein and DNA.Absolutely,the anti-tumor activity of Daphnane-type diterpenes is worthy of attention.Unfortunately,most of the current research on the activity of these compounds is focused on simple drug efficacy,and its in-depth mechanism research is far from enough.On the other point of view,there still exists wide growing space on the depth of these compounds.

关 键 词：anti-tumor effect bcompound structure Daphne genus Daphnane-type diterpenes molecular mechanism 

分 类 号：R284[医药卫生—中药学]