A review of lignans from genus Kadsura and their spectrum characteristics  

作　　者：Liu Zhang Yan-zhe Jia Bin Li Cai-yun Peng Yu-pei Yang Wei Wang Chang-xiao Liu 

机构地区：[1]TCM and Ethnomedicine Innovation&Development International Laboratory,School of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China [2]State Key Laboratory of Drug Delivery Technology and Pharmacokinetics,Tianjin Institute of Pharmaceutical Research,Tianjin 300193,China

出　　处：《Chinese Herbal Medicines》2021年第2期157-166,共10页中草药（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (No.81703819, 81874369 and 82074122);Natural Science Foundation of Hunan Province (No.2020JJ4463 and 2020JJ4064)。

摘　　要：Kadsura belongs to the Schisandroideae subfamily of Magnoliaceae.Plants from genus Kadsura are widely distributed in the South and Southwest of China.The plants of the genus are widely used as folk medicine for a long time in history,with the functions of relieving pain,promoting 'qi' circulation,activating blood resolve stasis,and applications in the treatment of rheumatoid arthritis and gastroenteric disorders.Lignans are the primary characteristic constituents with various biological activities of plants from genus Kadsura.This paper summarized 81 lignans isolated from the plants of genus Kadsura over the past eight years(from 2014 to 2021),which belong to five types:dibenzocyclooctadienes,spirobenzofuranoid dibenzocyclooctadienes,aryltetralins,diarylbutanes and tetrahydrofurans.Each type of these lignans possess typical characteristics in proton magnetic resonance(^(1)H NMR) and carbon-13 nuclear magnetic resonance(^(13)C NMR) spectra,the NMR regularities of these types of lingans were summarized,which provided a useful reference for the structural analysis of lignans.The relationships between lignans and pharmacodynamics were also systematically analyzed,lignans were predicted to be the quality markers(Q-marker) of Kadsura genus.

关 键 词：KADSURA ^(1)H NMR and^(13)C NMR spectrum CHARACTERISTICS PHARMACODYNAMICS Q-marker lignans structure classifications 

分 类 号：R284.1[医药卫生—中药学]