Hypoglycemic effects of Tibetan medicine Huidouba in STZ-induced diabetic mice and db/db mice  

作　　者：Ying-hui Bai Dong-xu Shi Hong-yu Lu Kun-bao Yang Huan-hu Zhao Bi-nan Lu Zong-ran Pang 

机构地区：[1]School of Pharmacy,Minzu University of China,Beijing 100081,China [2]Key Laboratory of Ethnomedicine,Ministry of Education,Minzu University of China,Beijing 100081,China [3]Chengde Medical University,Chengde 067000,China

出　　处：《Chinese Herbal Medicines》2021年第2期202-209,共8页中草药（英文版）

基　　金：supported by the National Natural Science Foundation of China (No.81673957);State Key Laboratory of Natural and Biomimetic Drug (No.K20160210);Independent Research Projects for Ph.D.Students of Minzu University of China (No.181084);Undergraduate Research and Training Program (URTP) of Minzu University of China (No.GCCX2020110018)。

摘　　要：Objective:Huidouba(HDB) is a Chinese folk medicine used to treat diabetes in Sichuan Province,China.Therefore,we investigated the anti-diabetic effects of HDB and its underlying mechanisms.We hypothesized that HDB treatment could enhance glucose tolerance and insulin sensitivity,and thus prevent a hyperglycemia state.Methods:To test the hypothesis,streptozotocin(STZ)-induced diabetic mice and db/db mice,widely used models of hyperglycemia and insulin-resistant diabetes,were either treated with HDB,metformin,or acarbose.Blood glucose,oral glucose tolerance test,insulin tolerance test,pancreatic histopathology and serum biochemistry were detected to assess the hypoglycemic effect of HDB.Results:HDB treatments were found to show the effect in reducing glucose levels.HDB also resulted in a significant reduction in body weight and food intake in the STZ-induced diabetic mouse model.Furthermore,it significantly improved glucose and insulin tolerance in the two diabetic mouse models.Importantly,insulin,glucagon,pancreatic polypeptide,and somatostatin immunohistochemistry revealed that HDB treatment improved the function and the location of the cells in the islets compared with the other two treatments.HDB treatment resulted in significant restoration of islet function.Our results illustrated the underlying mechanism of HDB in the progression of diabetes,and HDB can be an effective agent for the treatment of diabetes.Conclusion:The results of this study suggested that HDB can reduce blood glucose levels in STZ-induced hyperglycemic mice and db/db mice.

关 键 词：DYSLIPIDEMIA HUIDOUBA HYPERGLYCEMIA insulin secretion type 2 diabetes mellitus 

分 类 号：R29[医药卫生—民族医学]