线粒体质量控制体系在慢性阻塞性肺疾病发病机制中的作用  

Role of mitochondrial quality control in the pathogenesis of chronic obstructive pulmonary disease

作　　者：王素文 王炯[1] 李锋 Wang Suwen;Wang Jiong;Li Feng(Department of Respiratory and Critical Care Medicine,Anhui Geriatric Institute,the First Affiliated Hospital of Anhui Medical University,Hefei 230022,China;Department of Pulmonary and Critical Care Medicine,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China)

机构地区：[1]安徽医科大学第一附属医院老年呼吸科,合肥230022 [2]上海市胸科医院,上海交通大学附属胸科医院呼吸与危重医学科,200030

出　　处：《国际呼吸杂志》2021年第10期788-793,共6页International Journal of Respiration

基　　金：国家自然科学基金 (82070041);上海交通大学"交大之星"计划医工交叉研究基金重点项目 (YG2019ZDA24)。

摘　　要：慢性阻塞性肺疾病(COPD)是一种慢性炎症性气道疾病,具有高患病率和高病死率。线粒体是一个双层膜结构的动态细胞器,参与细胞的多种代谢过程,如能量生成、氧化应激和代谢物质的合成等。线粒体质量控制系统包括线粒体生成、线粒体动力学和线粒体自噬以维持线粒体的数量、质量和功能的稳定。越来越多的研究揭示出线粒体质量控制体系参与COPD的病理生理过程,如气道炎症、氧化应激、肺功能损伤等。本文概述线粒体质量控制系统在COPD发病机制中的作用以及相关治疗靶点在COPD治疗中的作用。Chronic obstructive pulmonary disease(COPD)is a chronic inflammatory lung disease with high morbidity and mortality.Mitochondria are dynamic organelles with double membrane structure,and are involved in many metabolic processes,such as energy production,oxidative stress and the synthesis of metabolites.The mitochondrial quality control system consists of mitochondrial biogenesis,mitochondrial dynamics and mitophagy and maintains the stability of mitochondria in terms of quality,quantity and function.More and more studies show that mitochondrial quality control system is involved in the pathogenetic process of COPD,such as airway inflammation,oxidative stress and lung function impairment.This review summarizes the role of mitochondrial quality control system in the pathogenesis of COPD and the role of related therapeutic targets in the treatment of COPD.

关 键 词：肺疾病 慢性阻塞性 线粒体生成 线粒体动力学 线粒体自噬 线粒体质量控制 

分 类 号：R563.9[医药卫生—呼吸系统]