新型脊柱外固定技术减少医源性脊旁肌损伤的动物模型研究  

Animal experimental study of new spinal external fixation surgery on paraspinal muscle injury

作　　者：李珊 彭文 晏怡果[1] 王程[1] 宋西正[1] 李学林[1] 欧阳智华[1] 薛静波[1] 王文军[1] Li Shan;Peng Wen;Yan Yiguo;Wang Cheng;Song Xizheng;Li Xuelin;Ouyang Zhihua;Xue Jingbo;Wang Wenjun(Department of Orthopaedic Surgery,The First Affiliated Hospital of University of South China,Hengyang 421001,Hunan Province,China;Technology Research and Development Center of Guangdong Stable Medical Technology Co,Ltd,FoShan 528200,Guangdong Province,China)

机构地区：[1]南华大学附属第一医院骨科研究所,湖南衡阳421001 [2]佛山市骨科内置物(施泰宝)工程技术研究中心,广东佛山528200

出　　处：《中国临床解剖学杂志》2021年第3期311-318,共8页Chinese Journal of Clinical Anatomy

基　　金：国家自然科学基金(31570946);湖南省研究生科研创新项目资助(CX2017B568);湖南省卫生计生委科研计划课题项目资助(A2017016)。

摘　　要：目的验证新型脊柱外固定技术较开放内固定手术减少医源性脊旁肌损伤的优势。方法取山羊10头,随机均分为脊柱外固定手术组和开放内固定手术组制作模型。术后3月处死模型动物,对手术节段腰椎行3.0 T MRI扫描,完整解剖脊旁肌组织行准静态拉伸实验及病理学切片,分析两种手术方式对脊柱脊旁肌的影响。结果成功构建山羊动物模型。相较开放内固定手术组,MRI示新型脊柱外固定技术组仅在螺钉周围出现少量的肌肉损伤,准静态拉伸力学实验、组织切片染色(HE染色、Masson染色)均提示新型脊柱外固定技术组肌肉损伤较少,有统计学差异。结论新型脊柱外固定技术通过经皮置钉以及外置矫形固定装置改进,可减少内固定装置挤压和干扰引发的脊旁肌损伤。Objective To verify the advantages of spinal external fixation surgery in reducing paraspinal muscle injury.Methods Ten goats were randomly divided into a spinal external fixation surgery group and an open internal fixation surgery group.The experimental animals were sacrificed at 3 months after operation.The lumbar vertebrae of the surgical segment were scanned by 3.0 T MRI,and the paraspinal muscle tissue was completely dissected for quasi-static tensile test and pathological section.The effects of the two surgical methods on paraspinal muscle were analyzed.Results The goat animal model was successfully constructed.MRI showed that compared with the open internal fixation surgery group,there were only a small amount of muscle injury around the screw in the spinal external fixation surgery group.Quasistatic tensile mechanical tests,tissue section staining(HE staining,Masson staining)all suggested that there was less muscle injury in the spinal external fixation surgery group.There are statistical differences.Conclusions The method of spinal external fixation through percutaneous nail implantation and external orthopedic fixation was verified to reduce the paraspinal muscle injury caused by postoperative internal fixation device compression and interference.

关 键 词：新型脊柱外固定器 山羊脊旁肌 手术损伤 动物实验 

分 类 号：R95-33[医药卫生—药学] R649.9