计算流体力学在组织工程中的应用进展  

Application advances in the computational fluid dynamics in tissue engineering

作　　者：唐辉 伍津津 TANG Hui;WU Jinjin(Department of Dermatology,Daping Hospital,Army Medical University,Chongqing,400042,P.R.China)

机构地区：[1]陆军军医大学大坪医院皮肤科,重庆400042

出　　处：《中国修复重建外科杂志》2021年第6期776-780,共5页Chinese Journal of Reparative and Reconstructive Surgery

基　　金：国家自然科学基金青年基金资助项目(31600776)。

摘　　要：目的综述计算流体力学(computational fluid dynamics,CFD)在组织工程中的应用进展。方法广泛查阅CFD应用于组织工程的相关文献,主要对CFD用于生物反应器设计改良或优化、模拟体外组织再生过程中的流体动力学和细胞生长动力学等方面进行综述。结果 CFD的模拟预测能力可为生物反应器的设计优化和体外组织工程组织培养提供重要的指导作用,且结合实验研究能进一步提高模型预测结果的准确性。结论 CFD作为新兴和有效的研究工具,已在组织工程中展现出独特优势并取得显著进展,但更全面、准确地模拟组织再生全过程仍需进一步研究。Objective To review the advances in the computational fluid dynamics(CFD) in tissue engineering.Methods The latest research of CFD applied to tissue engineering were extensively retrieved and analyzed, the optimization of bioreactor design and the simulation of fluid dynamics and cell growth kinetics during tissue regeneration in vitro were mainly reviewed. Results The simulation and predictive capabilities of CFD can provide important guidance for the optimization of bioreactor design, and the cultivation of engineering tissue. The accuracy of model prediction results can be further improved by combining with experimental research. Conclusion As a new and effective research tool, CFD has its unique advantages in the application of tissue engineering. However, a more comprehensive and accurate simulation of the whole process of tissue regeneration still needs further studies.

关 键 词：计算流体力学 组织工程 组织再生 生物反应器 应用进展 

分 类 号：O35[理学—流体力学] R318[理学—力学]