过敏性哮喘患儿FeNO的变化及与血清IgE表达的关系研究  

Changes of FeNO and its relationship with serum IgE expression in children with allergic asthma

作　　者：周峰 徐杰 钟林[1] ZHOU Feng;XU Jie;ZHONG Lin(Department of Laboratory,Jiangmen Maternal and Child Health Hospital,Guangdong Province,Jiangmen 529000,China;Department of Pediatrics,Jiangmen Maternal and Child Health Hospital,Guangdong Province,Jiangmen 529000,China)

机构地区：[1]广东省江门市妇幼保健院检验科,广东江门529000 [2]广东省江门市妇幼保健院儿内科,广东江门529000

出　　处：《中国当代医药》2021年第17期193-195,F0003,共4页China Modern Medicine

基　　金：广东省江门市医疗卫生科技计划项目(2019D015)。

摘　　要：目的探讨过敏性哮喘患儿呼出气一氧化氮(FeNO)的变化及与血清免疫球蛋白E(IgE)表达的关系。方法选择广东省江门市妇幼保健院2018年3月~2020年5月收治的120例过敏性哮喘患儿作为观察组,选择同期就诊的120例非过敏性哮喘患儿作为对照组。比较两组的FeNO和血清IgE水平,分析FeNO和血清IgE相关性,绘制受试者工作特征(ROC)曲线,分析FeNO、血清IgE单一与联合诊断过敏性哮喘的效能。结果观察组FeNO和血清IgE水平高于对照组,差异有统计学意义(P<0.05);Pearson相关性显示,FeNO和血清IgE水平呈正相关(r=0.743,P<0.05);FeNO和血清IgE联合诊断过敏性哮喘的AUC为0.917,特异度、敏感度分别为0.932、0.727,特异度高于各指标单一检测。结论过敏性哮喘患儿体内FeNO、IgE水平明显升高,两者呈正相关,联合检测能够提高过敏性哮喘检出率,可作为早期筛查过敏性哮喘的常用指标。Objective To explore the changes of fractional exhaled nitric oxide(FeNO)and its relationship with serum immunoglobulin(IgE)expression in children with allergic asthma.Methods From March 2018 to may 2020,120 children with allergic asthma admitted to Jiangmen Maternal and Child Health Hospital were selected as the observation group,while 120 children without allergic asthma were selected as the control group.The FeNO and serum IgE levels of the two groups were compared,the correlation between FeNO and serum IgE was analyzed,the receiver operating characteristics(ROC)curves of the subjects were drawn,and the efficacy of single or combined FeNO and serum IgE in the diagnosis of allergic asthma was analyzed.Results The FeNO and serum IgE levels in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).Pearson correlation showed that FeNO and serum IgE levels were positively correlated(r=0.743,P<0.05).The AUC of FeNO and serum IgE combined diagnosis of allergic asthma was 0.917,the specificity and sensitivity were 0.932 and 0.727 respectively,the specificity was higher than the single detection of each index.Conclusion The levels of FeNO and IgE in children with allergic asthma are significantly increased,and the two are positively correlated.Combined detection could improve the detection rate of allergic asthma and could be used as a common index for early screening of allergic asthma.

关 键 词：过敏性哮喘 特异性IGE抗体 呼出气一氧化氮 相关性 

分 类 号：R562.25[医药卫生—呼吸系统]