帕金森病感觉运动区脑功能网络连通性分析  

Functional network connectivity analysis in sensorimotor area of Parkinson’s disease

作　　者：潘钰 瞿航 赵义[1] 王苇[1] 刘姜冰 PAN Yu;QU Hang;ZHAO Yi;WANG Wei;LIU Jiangbing(Department of Imaging,Affiliated Hospital of Yangzhou University,Yangzhou 225000,China;Department of Neurology,Affiliated Hospital of Yangzhou University,Yangzhou 225000,China)

机构地区：[1]扬州大学附属医院影像科,扬州225000 [2]扬州大学附属医院神经内科,扬州225000

出　　处：《磁共振成像》2021年第4期6-11,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：江苏省卫生健康委员会科研课题(编号:Z201618);扬州大学科技创新培育基金(编号:2019CXJ206);扬州市“十三五”科教强卫工程重点学科资助项目(编号:ZDXK201806)。

摘　　要：目的采用独立成分分析和功能网络连通性分析方法,对比帕金森病患者与健康者大脑的感觉运动网络与其他网络间连通性差异,及感觉运动网络内各亚区间连通性的差异。材料与方法纳入2019年1~12月于扬州大学附属医院神经内科就诊的原发性帕金森病患者30例和同期招募的健康对照者30名。采集静息态功能磁共振数据和结构像磁共振数据,使用Restplus软件包对图像进行预处理,并使用GIFT软件包将2组受试者的大脑划分为53个独立成分,归为7个脑网络,计算各网络之间的连接强度,统计分析两组间各网络成分的连通性差异。将2组受试者大脑感觉运动网络划分18个独立成分,归为6个亚区,计算各亚区间的连接强度,统计分析两组间各亚区间连通性差异。并将存在统计学差异的成分间的连接强度与帕金森病统一评分量表(UPDRS-Ⅲ)做相关性分析。结果与健康对照组相比,帕金森病组感觉运动网络与高级视觉网络、注意网络间的连通性减少。在感觉运动网络内部,帕金森病患者的左侧中央前/后回与右侧中央前/回、中央旁小叶间的连通性均减少,但左侧中央前回与左侧中央后回的连通性增加。中央旁小叶与左侧中央前/后回的连接强度与UPDRS-Ⅲ评分存在显著负相关。结论与健康者相比,帕金森病患者无论是感觉运动网络与其他脑功能网络间的连通性,还是感觉运动网络内的连通性都存在差异,且大部分呈连接强度减弱趋势,提示脑功能连接异常可能是导致帕金森病患者运动功能障碍如静止性震颤、肌强直、运动迟缓等症状产生的原因之一。Objective:To investigate the connectivity intensity differences of whole-brain network and the sensorimotor network between Parkinson’s disease patients(PD)and healthy control subjects(HC)by using independent component analysis(ICA)and functional network connectivity(FNC)analysis.Materials and Methods:We recruited 30 primary Parkinson’s disease patients who have enrolled in the department of neurology,the affiliated Hospital of Yangzhou University,and 30 healthy control subjects from January to December 2019,and performed resting state functional imaging scans.The whole brain was divided into 53 independent components(IC)and classified into seven brain networks by GIFT software package.Functional networks of the whole brain were compared by two-sample t-test.The sensorimotor network was divided into 18 IC and classified into six subregions.Functional subregions of the sensorimotor network were compared by two-sample t-test.Ultimately,we evaluated the connectivity intensity and Parkinson’s Disease Rating Scale(UPDRS-Ⅲ)Scores in PD patients.Results:Compared with HC group,it was found that the connectivity intensity between sensorimotor network and high-level visual network,as well as attention network was decreased in PD group.Within the sensorimotor network,the connectivity intensity between left precentral gyrus and right precentral gyrus,as well as paracentral lobule was decreased,but the connectivity intensity was increased between left precentral gyrus and left postcentral gyrus.Correlation analysis showed that the connectivity intensity between paracentral lobule and left precentral gyrus and left postcentral gyrus was negatively correlated with UPDRS-ⅢScore.Conclusions:Compared with the healthy control group,there are connectivity differences between the functional networks of whole brain,and between the subregions of sensorimotor network in Parkinson’s disease patients.And most of the connectivity intensity in PD patients were weaker than HC.It was suggested that abnormal brain functional connec

关 键 词：帕金森病 功能磁共振成像 独立成分分析 功能网络连通性 感觉运动网络 

分 类 号：R445.2[医药卫生—影像医学与核医学] R742.5[医药卫生—诊断学]