Nogo在心脏中的分布及其在心血管疾病中的作用  

Distribution of Nogo in the heart and its role in cardiovascular disease

作　　者：张苏欣 孙艳荣 王文娟 孙昊哲 胡耀文 秦丽华 ZHANG Su-xin;SUN Yan-rong;WANG Wen-juan;SUN Hao-zhe;HU Yao-wen;QIN Lin-hua(Clinic Class 4,Grade 2017;Department of Human Anatomy and Histoembryology,School of Basic Medical Sciences;Clinic Eight-Year Program,Grade 2015,Peking University Health Science Center,Beijing 100083,China)

机构地区：[1]北京大学医学部,北京100083 [2]北京大学医学部基础医学院人体解剖学与组织学胚胎学系

出　　处：《解剖学报》2021年第3期495-498,共4页Acta Anatomica Sinica

基　　金：国家自然科学基金(81873818)。

摘　　要：Nogo作为网状蛋白家族成员,主要参与组织损伤后再生、细胞凋亡和肿瘤生长等过程。心血管疾病是目前威胁人类健康的主要疾病之一。近年来关于Nogo在心血管系统的研究愈加广泛,在心肌纤维化、心肌细胞凋亡和血管重塑等病理过程中Nogo表达的变化提示其可能发挥一定的作用。本文中我们就Nogo在心脏中的分布及心血管疾病中作用作一综述,以揭示其在心血管疾病中可能的作用与机制。As a member of the reticulin family,Nogo is mainly involved in processes such as tissue regeneration,apoptosis and tumor growth after tissue injury.Cardiovascular disease is one of the main diseases that threaten human health at present.In recent years,research on Nogo in the cardiovascular system has become increasingly extensive.Changes in the expression of Nogo during myocardial fibrosis,myocardial cell apoptosis and vascular remodeling suggest that it may play a certain role.This article reviews the distribution of Nogo in the heart and its role in cardiovascular disease,in order to reveal its possible role and mechanism in cardiovascular diseases.

关 键 词：NOGO 心肌梗死 心力衰竭 心肌细胞凋亡 心肌纤维化 冠状血管调控 

分 类 号：R34[医药卫生—基础医学]