Fonsecaea monophora所致海南渔民着色芽生菌病1例  

A case of Chromoblastomycosis caused by Fonsecaea monophora in Hainan fisherman

作　　者：牛牧 廖万清 吴伟伟 郑文爱 NIU Mu;LIAO Wanqing;WU Weiwei;ZHENG Wenai(Department of Dermatologic surgery/Pathology,The fifth people’s hospital of Hainan Province,Haikou 571101,China;Department of Dermatology,Second Affiliated Hospital of Naval Medical University,Shanghai 200003,China;Department of Laboratory Medicine,The fifth people’s hospital of hainan province,Haikou 571101,China)

机构地区：[1]海南省第五人民医院科室皮肤外科,海口571100 [2]海军军医大学第二附属医院皮肤科,上海200003 [3]海南省第五人民医院科室检验科,海口571100

出　　处：《中国真菌学杂志》2021年第3期184-187,共4页Chinese Journal of Mycology

摘　　要：患者,男,80岁,渔民,捕鱼时右手腕关节擦伤后出现棕褐色结节11年。组织病理检查:慢性肉芽肿样改变,HE和PAS染色均可见到圆形、厚壁、棕色的硬壳小体。ITS区序列分析鉴定为Fonsecaea monophora。诊断为着色芽生菌病,予抗真菌联合治疗(伊曲康唑0.2 g,1次/d,特比萘芬0.25 g,1次/d),治疗4个月后患者疣状斑块增生明显好转,随访中。Here we report a case of chromoblastomycosis caused by Fonsecaea momophora.A 80-year-old man was admitted to the hospital with a more than eleven years’s history of plaque on the right hand.Direct microscopic examination and fungal culture,histopathologic examination,ribosomal internal transcribed spacer(ITS)sequence analysis were performed.The thick-walled,brown sclerotic bodies were observed by direct microscopic examination and histopathological examination.Fungal culture yielded black brown villiform colonies and rhinocladiella type and cladosporium type conidia were observed in the slide culture.The isolate was identified as Fonsecaea momophora according to the ITS sequencing.The patient was prescribled itraconazole(200 mg/d)combined with terbinafine(250 mg/d)for 4 months.The lesions improved greatly and the patient was now under followed-up.

关 键 词：Fonsecaea monophora 着色芽生菌病 伊曲康唑 特比萘芬 皮下真菌感染 

分 类 号：R756.6[医药卫生—皮肤病学与性病学]