基于微流控技术的药敏实验方法在中药领域的应用概述及前景展望  

Overview and prospect of drug sensitivity test method based on microfluidic technology in traditional Chinese medicine

作　　者：冯京[1] 郑玉玲 邢龄艺 冉棋 宋新波[1,2] 张丽娟 李薇[1] FENG Jing;ZHENG Yuling;XING Lingyi;RAN Qi;SONG Xinbo;ZHANG Lijuan;LI Wei(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Tianjin Modern Innovative Chinese Medicine Technology Co.Ltd.,Tianjin 300191,China)

机构地区：[1]天津中医药大学,天津301617 [2]天津现代创新中药科技有限公司,天津300191

出　　处：《天津中医药大学学报》2021年第3期389-395,共7页Journal of Tianjin University of Traditional Chinese Medicine

基　　金：重大新药创制科技重大专项项目(2018ZX09201011)。

摘　　要：药物敏感实验是常用的判定细菌耐药性的方法,高效准确的细菌敏感性检测技术不仅有助于抗生素在临床上的正确使用,而且能加快新抗菌药物的研发速度。中药成分复杂、颜色较深等特点使得传统的实验方法在其敏感性测定中存在一定的局限性。微流控技术因其微型化、高通量化和集成化等特点,在药物敏感实验中具有独特的优势。文章总结了微流控药敏实验的芯片系统及实验方法,为其在中药领域的研究提供了新的思路。Drug sensitivity test is a common method to determine bacterial drug resistance.Effective and accurate bacterial sensitivity detection technology not only contributes to the correct use of antibiotics in clinical practice,but also can accelerate the development of new antimicrobial drugs.Traditional test methods have some limitations in the sensitivity determination of traditional Chinese medicine due to its complex composition and dark color.Microfluidic technology has its unique advantages in drug sensitivity test due to its miniaturization,high-pass quantization and integration.In this paper,the microfluidic drug sensitivity experiment chip system and method are summarized,which provides a new idea for its research in the field of traditional Chinese medicine.

关 键 词：药物敏感实验 中药 微流控技术 细菌耐药性 

分 类 号：R2-03[医药卫生—中医学]