西地兰联合美托洛尔用于急性左心衰竭合并房颤患者的治疗效果及预后评价  

Therapeutic Effect and Prognosis Evaluation of Cedilanid Combined with Metoprolol in Patients with Acute Left Heart Failure Complicated with atrial fibrillation

作　　者：陈敬苏 CHEN Jingsu(Department of Pharmacy,Jinzhou Hospital of Traditional Chinese Medicine,Jizhou 121000,China)

机构地区：[1]辽宁省锦州市中医医院药剂科,辽宁锦州121000

出　　处：《中国医药指南》2021年第13期78-79,共2页Guide of China Medicine

摘　　要：目的探讨西地兰联合美托洛尔用于急性左心衰竭合并房颤患者的治疗效果,并对患者预后评价情况进行总结。方法选所在医院2016年8月至2018年9月收治的68例急性左心衰竭合并房颤患者,根据治疗方法分组,对照组34例患者单纯采用美托洛尔,观察组(n=34)在此基础上联合西地兰进行治疗,对比两组患者临床疗效。结果观察组总有效率(94.12%)高于对照组(73.53%),对比差异显著(P<0.05);观察组患者治疗后血浆APN水平、hs-CRP明显优于对照组(P<0.05);观察组呼吸困难、房颤、咳嗽改善时间低于对照组(P<0.05);观察组用药期间不良反应发生率(5.88%)略低于对照组(11.76%),但是两组数据对比差异无统计学意义(P>0.05)。结论西地兰联合美托洛尔在治疗急性左心衰竭合并房颤中临床效果明显,可快速改善患者临床症状,临床效果满意,是安全有效的临床用药方案。Objective To investigate the efficacy of cedilanid combined with metoprolol in the treatment of patients with acute left heart failure combined with atrial fibrillation,and to summarize the prognostic evaluation of patients.Methods Six-eight patients with acute left heart failure and atrial fibrillation admitted to our hospital from August 2016 to September 2018 were selected.According to the treatment method group,34 patients in the control group were treated with metoprolol alone,while the observation group(n=34)was treated with cedilanid on this basis.The clinical efficacy of the two groups was compared.Results The total effective rate of the observation group(94.12%)was higher than that of the control group(73.53%),the difference was significant(P<0.05);the plasma APN level and hs-CRP of the observation group were significantly better than those of the control group(P<0.05);the improvement time of dyspnea,atrial fibrillation and cough in the observation group was lower than that in the control group(P<0.05);the incidence of adverse reactions(5.88%)was slightly lower than that of the control group(11.76%),but there was no significant difference between the two groups(P>0.05).Conclusion Cedilanid combined with metoprolol has obvious clinical effects in the treatment of acute left heart failure combined with atrial fibrillation,and can quickly improve the clinical symptoms of patients with satisfactory clinical effects.

关 键 词：西地兰 美托洛尔 急性左心衰竭 房颤 

分 类 号：R541.6[医药卫生—心血管疾病]