银屑病并发人免疫缺陷病毒感染治疗进展  

Progress in the treatment of psoriasis complicated with HIV infection

作　　者：唐珂韵 刘润竹 张翰林 晋红中[1] TANG Ke-yun;LIU Run-zhu;ZHANG Han-lin(Department of Dermatology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100730,China)

机构地区：[1]中国医学科学院北京协和医学院北京协和医院皮肤科,北京100730

出　　处：《实用皮肤病学杂志》2021年第2期95-98,共4页Journal of Practical Dermatology

摘　　要：人免疫缺陷病毒(human immunodeficiency virus,HIV)感染可能会增加银屑病的发病率。感染HIV的银屑病患者临床表现严重且不典型,治疗较困难且易复发。该文综述银屑病并发HIV感染的临床表现、治疗进展和可能的发病机制,为临床诊治并发HIV感染的银屑病提供参考。HIV阳性的银屑病患者中,轻度至中度银屑病的一线疗法为局部外用药;中度至重度银屑病的一线疗法为高效抗逆转录病毒疗法和光照疗法,二线疗法为口服阿维A。生物制剂和传统口服免疫抑制剂不作为并发HIV感染银屑病的常规疗法,仅用于难治性重症银屑病的短期治疗。Human immunodeficiency virus(HIV)infection is associated with a higher incidence of psoriasis,and such psoriasis patients usually present with more atypical and exuberant lesions,frequently refractory to therapy and easily to relapse.This review summarizes current treatments and promising therapeutic choices for psoriasis in HIV-infected patients as well as its possible pathogenesis and clinical presentation.In HIV-positive psoriasis patients,as the first-line therapy,topical preparations may be for mild to moderate cases,and UV therapy and highly active antiretroviral medicines for moderate to severe ones.Oral retinoids is the second-line treatment for moderate to severe psoriasis cases.Classical immunosuppressants and biologics are not recommended in routine management,which would only be used in severe and refractory cases for a short term.

关 键 词：银屑病 感染 人免疫缺陷病毒 艾滋病 临床治疗 免疫抑制 

分 类 号：R758.62[医药卫生—皮肤病学与性病学] R512.91[医药卫生—临床医学]