肝硬化腹水患者血清CK18 FGF-21水平与食管静脉曲张破裂出血及肝功能分级间的关系  

Relationship between the Levels of Serum CK18 and FGF-21 with Bleeding from Esophageal Varices and Liver Function Classification in Patients with Liver Cirrhosis Ascites

作　　者：张顺利 沈丽娟[2] 赵海明 王玉芬[1] ZHANG Shunli(Qinghai Red Cross Hospital, Qinghai Xining 810000, China)

机构地区：[1]青海红十字医院消化内科,青海西宁810000 [2]青海大学附属医院消化内科,青海西宁810000

出　　处：《河北医学》2021年第6期958-963,共6页Hebei Medicine

基　　金：国家卫生计生委医药卫生科技发展项目,(编号:W2016EWQT22)。

摘　　要：目的:分析肝硬化腹水患者血清细胞角蛋白18(CK18)、成纤维细胞生长因子21(FGF-21)、表达水平与食管静脉曲张(EV)破裂出血及肝功能分级的关系。方法:选取本院245例肝硬化腹水患者,检测血清CK18、FGF-21水平,比较不同肝功能Chid-Pugh分级患者血清CK18、FGF-21水平,进行相关性分析;按照EV是否破裂出血分为出血组与未出血组,分析EV破裂出血影响因素。结果:肝功能A级患者CK18水平明显低于B级与C级,B级明显低于C级(P<0.05);肝功能A级患者FGF-21水平明显高于B级与C级,B级明显高于C级(P<0.05);肝功能分级与CK18呈正相关(P<0.05),与FGF-21呈负相关(P<0.05);出血组与未出血组在EV程度、肝功能Chid-Pugh分级、CK18、FGF-21表达水平差异具有统计学意义(P<0.05);Logistic分析显示,肝功能Chid-Pugh分级、CK18属于EV破裂出血危险因素(P<0.05),FGF-21属于保护因素(P<0.05)。结论:肝硬化腹水患者血清CK18、FGF-21表达水平与EV破裂出血及肝功能分级密切相关。Objective:To analyze the relationship of the expression levels of serum cytokeratin 18(CK18)and fibroblast growth factor 21(FGF-21)with bleeding from esophageal varices(EV)and liver function classification in patients with liver cirrhosis ascites.Methods:245 patients with liver cirrhosis ascites were selected and their serum CK18 and FGF-21 levels were tested.Serum CK18 and FGF-21 levels of patients with different Chid-Pugh grades of liver function were compared,and correlation analysis was carried out.According to the presence or absence of bleeding from EV,the patients were divided into bleeding group and non-bleeding group.Factors affecting bleeding from EV were analyzed.Results:CK18 levels of patients with grade A,grade B,and grade C liver function increased in turn(P<0.05),while FGF-21 levels of patients with grade A,grade B,and grade C liver function decreased in turn(P<0.05).The grade of liver function was positively correlated with CK18(P<0.05),and negatively correlated with FGF-21(P<0.05).There were statistically significant differences between the bleeding group and the non-bleeding group in terms of EV degree,Chid-Pugh classification of liver function,CK18 and FGF-21 expression levels(P<0.05).Logistic analysis showed that Chid-Pugh classification of liver function and CK18 were risk factors for bleeding from EV(P<0.05),while FGF-21 was a protective factor(P<0.05).Conclusion:The expression levels of serum CK18 and FGF-21 in patients with liver cirrhosis ascites are closely related to bleeding from EV and liver function classification.

关 键 词：肝硬化腹水 细胞角蛋白18 成纤维细胞生长因子21 食管静脉曲张 破裂出血 Chid-Pugh分级 

分 类 号：R58[医药卫生—内分泌]