左束支阻滞电生理机制研究进展  

Research progress in electrophysiological mechanism of left bundle branch block

作　　者：刘彤[1] 王鑫 LIU Tong;WANG Xin(Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular Disease,Department of Cardiology of the Second Hospital of Tianjin Medical University,Tianjin Institute of Cardiology,Tianjin 300211,China)

机构地区：[1]天津市心血管病离子与分子机能重点实验室,天津医科大学第二医院心脏科,天津心脏病学研究所,天津300211

出　　处：《实用心电学杂志》2021年第3期159-163,共5页Journal of Practical Electrocardiology

摘　　要：左束支阻滞(left bundle branch block,LBBB)比右束支阻滞更少见,且多为病理性LBBB。因LBBB改变了正常的心脏激动顺序,致使左、右心室电机械不同步,易发生心室重构,增加心力衰竭等不良心脏事件发生的风险。本文主要针对LBBB的电机械非同步化及其致病基因相关的电生理机制进行综述。Left bundle branch block(LBBB)is less common than right bundle branch block,and mostly pathological.Since LBBB changes the sequence of normal cardiac activation,resulting in electro-mechanical nonsynchronization of the left and right ventricles,it is prone to cause ventricular remodeling,and increase the risk of heart failure and other adverse cardiac events.This review mainly focuses on the research progress in the electromechanical non-synchronization and pathogenic gene related electrophysiological mechanisms of LBBB.

关 键 词：左束支阻滞 电机械非同步 心室重构 

分 类 号：R541.76[医药卫生—心血管疾病]