单侧全聋型突发性聋患者失匹配负波的初步研究  

A preliminary study on the negative wave mismatch in patients with unilateral total sudden deafness

作　　者：胡萍萍 朱斌 孟子珅 袁玲 曹诗瑶 关兵 HU Pingping;ZHU Bin;MENG Zishen;YUAN Ling;CAO Shiyao;GUAN Bing(Dalian Medical University,Dalian,116000,China;Department of Otolaryngology Head and Neck Surgery,North Jiangsu People’s Hospital Affiliated to Clinical Medical College of Yangzhou University)

机构地区：[1]大连医科大学,辽宁大连116000 [2]扬州大学临床医学院附属苏北人民医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2021年第5期391-394,共4页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

摘　　要：目的:观察单侧全聋型突发性聋(突聋)患者失匹配负波(MMN)的特点,与正常人MMN相比较,从而为探讨单侧全聋型突聋的病理生理机制和治疗提供理论依据。方法:设26例单侧全聋型突聋患者作为实验组,25名正常健康人为对照组,分别对两组受试者进行MMN检查,采用经典的oddball模式,标准刺激和偏差刺激分别为1000 Hz和2000 Hz的短纯音测试两组受试者MMN,观察两组MMN潜伏期及波幅的特点,并比较两组间潜伏期及波幅的差异。结果:51例受试者中仅1例全聋型突聋患者未引出MMN波形,其余均引出,实验组MMN潜伏期为(162.03±38.64)ms,波幅为(2.83±1.14)μV,年龄为(48.64±10.27)岁;对照组MMN潜伏期为(197.52±27.43)ms,波幅为(2.58±1.07)μV,年龄为(45.00±8.20)岁。两组间MMN潜伏期差异有统计学意义(P<0.01),波幅差异无统计学意义(P>0.05),年龄差异亦无统计学意义(P>0.05)。结论:急性期突聋患者听觉中枢功能发生了改变,推测可能急性期突聋患者听觉中枢出现相应应急变化,从而使其功能发生了适应性改变,这为日后探讨突聋的病理生理机制及治疗方案提供了进一步的参考依据。Objective:To observe the characteristics of different negativity negativity(MMN)in patients with unilateral sudden deafness,and compare them with normal MMN,in order to provide theoretical reference for discussing the pathogenesis of unilateral sudden deafness and their relationship with the auditory centers,and to provide theoretical basis for the treatment of sudden deafness in the future.Methods:Twenty-six cases of unilateral total sudden deafness were recruited as experimental group,25 cases of normal healthy people as control group,the MMN inspections was performed respectively,the two groups using classical mode of oddball,standard and deviation stimulate with 1000 Hz and 2000 Hz short pure tone test MMN respectively,to observe the MMN latency and amplitude characteristics,and compare the latent period and amplitude difference between the two groups.Results:Among the 51 subjects,only 1 patient with unilateral total sudden deafness did not elicit MMN waveform,while the rest were all induced.The average incubation period of MMN in the experimental group was(162.03±38.64)ms,the average amplitude was(2.83±1.14)μV,and the mean age was(48.64±10.27)y.While the average incubation period of MMN in the control group was(197.52±27.43)ms,the average amplitude was(2.58±1.07)μV,and the mean age was(45.00±8.20)y.The MMN latency was significantly different between the two groups(P<0.01).There was no statistical difference in amplitude between the two groups(P>0.05).There was no statistical difference in age between the two groups(P>0.05).Conclusion:The latency period of MMN of unilateral total sudden deafness is shorter than that of the control group.It suggests that the auditory center function of patients with acute sudden deafness has changed,and we speculate that the auditory center of patients with acute sudden deafness may have corresponding emergency changes,so as to make its function have adaptive changes,which will provide further reference for the discussion of the pathophysiological mechanism and treatme

关 键 词：突发性聋 失匹配负波 听觉中枢 听觉剥夺 听觉重塑 

分 类 号：R764.43[医药卫生—耳鼻咽喉科]