输尿管支架管相关尿路感染及抗菌生物材料的研究进展  

Research progress of ureteral stent-related urinary tract infection and antibacterial biomaterials

作　　者：徐彬[1] 王子源 刘春(审校)[2] XU Bin;WANG Ziyuan;LIU Chun(First Clinical Medical College,Shanxi Medical University,Taiyuan,030001,China;Department of Urology,First Affiliated Hospital of Shanxi Medical University)

机构地区：[1]山西医科大学第一临床医学院,太原030001 [2]山西医科大学第一医院泌尿外科

出　　处：《临床泌尿外科杂志》2021年第5期406-411,共6页Journal of Clinical Urology

基　　金：山西省重点研发计划项目(No:201803D31101)。

摘　　要：输尿管支架管是泌尿外科常用的临时植入物之一,然而由于细菌易黏附到留置的植入物表面上形成生物膜,使得相关尿路感染的机制变得更为复杂。生物膜一旦形成便很难去除,即便使用大剂量抗生素也不易治愈,并且易躲避免疫机制的杀伤,有可能发展为难治性感染,严重者甚至形成脓毒症。因此,了解其发病机制具有重要意义。本文就输尿管支架管导致尿路感染的相关机制以及新材料的运用进行综述,从而为输尿管支架管的改进以及输尿管支架应用于下尿路感染的预防和控制提供策略。The ureteral stent is one of the temporary implants commonly used in urology.However,because bacteria adhere to the surface of indwelling implants and subsequently form a biofilm layer,the related urinary tract infection mechanism becomes more complicated.Once the biofilm is formed,it’s difficult to remove.Even if a large doses of antibiotics is used,it’s not easy to cure,and it’s easy to avoid the killing of immune mechanisms.It may develop to refractory infections,and even sepsis in severe cases.Therefore,it is important to understand its pathogenesis.This article reviews the related mechanisms of ureteral stents leading to urinary tract infections and the application of new materials,so as to provide strategies for the improvement of ureteral stents and the prevention and control of lower urinary tract infections.

关 键 词：输尿管支架管 尿路感染 生物膜 抗菌生物材料 

分 类 号：R693[医药卫生—泌尿科学]