高龄患者hCG注射后授精时间对妊娠结局的影响  

Influence of Insemination Time After hCG Injection on Pregnancy Outcome in Elderly Patients

作　　者：廖晖淇 陈鑫 徐鸿毅 刁红录 张昌军[1,2,3,5] LIAO Hui-qi;CHEN Xin;XU Hong-yi;DIAO Hong-lu;ZHANG Chang-jun(Reproductive Medicine Cen-ter,Renmin Hospital,Hubei University of Medicine;Hubei Clinical Research Center for Reproductive Medicine;Biomedical Engineering College,Hubei University of Medicine;Biomedical Research Institute,Hubei University of Medicine;Hubei Key Laboratory of Embryonic Stem Cell Research,Hubei University of Medicine,Shiyan,Hubei 442000,China)

机构地区：[1]十堰市人民医院·湖北医药学院附属人民医院生殖医学中心 [2]湖北省生殖医学临床医学研究中心 [3]湖北医药学院生物医学工程学院 [4]湖北医药学院生物医药研究院 [5]湖北医药学院胚胎干细胞湖北省重点实验室,湖北十堰442000

出　　处：《湖北医药学院学报》2021年第3期245-249,共5页Journal of Hubei University of Medicine

基　　金：湖北省自然科学基金创新群体(2020CFA021);湖北省自然科学基金项目(2015CFB543)。

摘　　要：目的:探讨高龄患者人绒毛膜促性腺激素(human chorionic gonadotropin,hCG)注射后受精时间对妊娠结局的影响。方法:回顾性分析2019年1月-2019年12月期间在湖北省十堰市人民医院生殖医学中心接受体外受精-胚胎移植(in vitro fertilization-embryo transfer,IVF-ET)助孕的高龄患者200例,按hCG注射后授精时间分为2组,一组注射后(39.0±1.0)h授精(102例),另一组hCG注射后(42.0±1.0)h授精(98例),比较不同授精时间对高龄患者妊娠结局的影响。结果:2组患者的年龄、不孕年限、Gn总量、获卵数等差异均无统计学意义,与hCG注射后(39.0±1.0)h授精组相比,hCG注射后(42.0±1.0)h授精组MII卵数增多,优质胚胎率提高,早期流产率降低,活产率升高,差异具有统计学意义(P<0.01)。结论:高龄患者hCG注射后(42.0±1.0)h授精可提高优质胚胎率,改善妊娠结局。Objective To investigate the effect of fertilization time after the injection of human chorionic gonadotropin(hCG)on the outcome of pregnancy in elderly patients.Methods A total of 200 elderly patients who received in vitro ferti⁃lization embryo transfer(IVF-ET)in the reproductive medicine center of Shiyan Renmin Hospital from January 2019 to December 2019 were retrospectively analyzed.According to the time of insemination after hCG injection,they were divided into two groups,group A:(39.0±1.0)h insemination after hCG injection(102 cases)and group B:(42.0±1.0)h insemi⁃nation after hCG injection(98 cases).The effects of different insemination time on pregnancy outcome of elderly patients were compared.Results There were no statistically significant differences in the age,infertility years,total Gn,and num⁃ber of eggs obtained between the two groups.Compared with the(39.0±1.0)h insemination group after hCG injection,in(42.0±1.0)h after hCG injection group,the number of MII eggs insemination increased,the rate of high-quality embryos increased,the rate of early abortion decreased,and the rate of live births increased.The difference was statistically signifi⁃cant(P<0.01).Conclusion Insemination 42 h after hCG injection in elderly patients can increase the rate of high-quality embryos and improve pregnancy outcomes.

关 键 词：高龄 体外受精 授精时间 临床妊娠率 优质胚胎率 

分 类 号：R714.8[医药卫生—妇产科学]