Preparation of Alum-borneol-PVP Drug-loaded Fibers by Electrospinning  

作　　者：HUANG Libing LIU Yueqi SANG Xinyu SONG Jinghui HU Ping LIU Yong 

机构地区：[1]College of Mechanical and Electric Engineering,Beijing University of Chemical Technology,Beijing,100029,P.R.China [2]Beijing Key Laboratory of Advanced Functional Polymer Composites,College of Materials Science and Engineering,Beijing University of Chemical Technology,Beijing,100029,P.R.China

出　　处：《Chemical Research in Chinese Universities》2021年第3期411-418,共8页高等学校化学研究（英文版）

基　　金：Supported by the National Natural Science Foundation of China(No.21374008).

摘　　要：The alum-borneol nanoemulsion(ABN),which combines the mineral medicine alum and the botanical medicine borneol,has been applied for approximately 40 years in the clinical treatment of burns,scalds,radiation dermatitis and shingles,and has a good curative effect.However,the current formula and dosage form of ABN pose problems of low borneol content and ease of precipitation,which greatly affects the efficacy of the drug.In this study,polyvinylpyrrolidone(PVP)was selected as a carrier mixed with different proportions of alum and borneol to produce alum-borneol-PVP fibers(ABPF)by electrospinning.The results showed that the stable system with good drug dispersion was 2:3(alum:borneol).The dissolution content of borneol from the ABPF was about 80%in 4 h,which was much higher than that of the alum-borneol liquid(ABL)and ABN.The ABPF membrane showed a more significant inhibitory effect on Staphylococcus aureus than the ABL and ABN.The composite fiber markedly increased the drug content of borneol,which was 800 times of that in ABN.The fiber had a higher solubility than the nanoemulsion in vitro,which is of great importance for the development of new forms for the clinical application of alum and borneol.

关 键 词：Drug delivery Dissolution content BIOAVAILABILITY ANTIBACTERIAL Fiber membrane 

分 类 号：R318[医药卫生—生物医学工程]