Electrospun Aspirin/Eudragit/Lipid Hybrid Nanofibers for Colon-targeted Delivery Using an Energy-saving Process  

作　　者：WANG Yibin TIAN Liang ZHU Tianhao MEI Jing CHEN Zezhong YU Deng-Guang 

机构地区：[1]School of Materials Science&Engineering,University of Shanghai for Science&Technology,Shanghai,200093,China [2]Shanghai Engineering Technology Research Center for High-Performance Medical Device Materials,Shanghai,200093,China

出　　处：《Chemical Research in Chinese Universities》2021年第3期443-449,共7页高等学校化学研究（英文版）

基　　金：This study was supported by the Natural Science Foundation of Shanghai,China(No.20ZR1439000);the USST college student innovation projects,China(Nos.SH2020227&XJ2020376-2020378).

摘　　要：Both electrospinning apparatus and their commercial products are extending their applications in a wide variety of fields.However,very limited reports can be found about how to implement an energy-saving process and in turn to reduce the production cost.In this paper,a brand-new type of coaxial spinneret with a solid core and its electrospinning methods are developed.A novel sort of medicated Eudragit/lipid hybrid nanofibers are generated for providing a colon-targeted sustained release of aspirin.A series of characterizations demonstrates that the as-prepared hybrid nanofibers have a fine linear morphology with the aspirin/lipid separated from the matrix Eudragit to form many tiny islands.In vitro dissolution tests exhibit that the hybrid nanofibers are able to effectively prevent the release of aspirin under an acid condition(8.7%±3.4%for the first two hours),whereas prolong the drug release time period under a neutral condition(99.7±4.2%at the seventh hour).The energy-saving mechanism is discussed in detail.The prepared aspirin-loaded hybrid nanofibers can be further transferred into an oral dosage form for potential application in countering COVID-19 in the future.

关 键 词：Coaxial spinneret Polymer/lipid hybrid fibers Colon-targeted ASPIRIN COVID-19 

分 类 号：R318.08[医药卫生—生物医学工程]