Green Electrospun Silk Fibroin Nanofibers Loaded with Cationic Ethosomes for Transdermal Drug Delivery  

作　　者：HONG Huoyan ZHANG Dongdong UN Si HAN Feng WANG Kaili JIANG Di WU Jinglei MO Xiumei WANG Hongsheng 

机构地区：[1]Key Laboratory of Science&Technology of Eco-Textile,Ministry of Education,Shanghai Engineering Research Center of Nano-Biomaterials and Regenerative Medicine,College of Chemistry,Chemical Engineering and Biotechnology,Donghua University,Shanghai,201620,P.R.China

出　　处：《Chemical Research in Chinese Universities》2021年第3期488-495,共8页高等学校化学研究（英文版）

基　　金：This work was supported by the Project of the Science&Technology Commission of Shanghai Municipality,China(Nos.18490740400,20DZ2254900).

摘　　要：Transdermal drug delivery system(TDDS)facilitates the controlled release of active ingredients penetrating through the skin,avoiding the liver first pass effect.Electrospinning is a simple process to fabricate ultrafine fibers with a higher specific surface area,making them excellent candidates for drug delivery.In current work,a novel silk fibroin(SF)nanofiber loaded with cationic ethosomes(CEs)was prepared via green electrospinning.The data of Fourier transform infrared spectroscopy(FTIR)and laser scanning confocal microscopy(LSCM)confirmed the existence of CEs in the SF nanofibers.The morphology of the nanofibers was not significantly affected by the incorporation of CEs as shown by scanning electron microscopy(SEM)images.The CEs-loaded SF nanofibrous patch(CEs-SFnP)showed good cytocompatibility as proved by both cell counting Kit-8(CCK-8)assay and SEM.Using doxorubicin hydrochloride(Dox)as a model drug,the transdermal performance of CEs-SFnP was evaluated through Franz diffusion cell against mouse skin.The results indicated that CEs-SFnP can effectively deliver drug into the skin,with a much higher permeation rate than the normal nanofibers without CEs.The as-spun CEs-SFnP in this study could find promising applications in TDDS.

关 键 词：Transdermal drug delivery Silk fibroin Ethosome Green electrospinning 

分 类 号：R318[医药卫生—生物医学工程]