补中益气汤治疗变应性鼻炎的Meta分析  

Meta-analysis of Buzhong Yiqi Decoction in the Treatment of Allergic Rhinitis

作　　者：龚美萍 陈思文 向红 彭斌[2] GONG Meiping;CHEN Siwen;XIANG Hong;PENG Bin(Graduate School of Hunan University of traditional Chinese Medicine,Changsha 410208,China;Second Affiliated Hospital of Hunan University of traditional Chinese Medicine,Changsha410005,China)

机构地区：[1]湖南中医药大学研究生院,湖南长沙410208 [2]湖南中医药大学第二附属医院,湖南长沙410005

出　　处：《中国民族民间医药》2021年第11期77-80,共4页Chinese Journal of Ethnomedicine and Ethnopharmacy

摘　　要：目的:系统评价补中益气汤治疗变应性鼻炎(AR)的临床疗效及安全性。方法:在知网、万方、维普、PubMed、生物医学全文数据库、Cochrane图书馆中检索补中益气汤治疗AR的临床实验,文献检索时间从建库至今,语种涵盖中英文。对筛选后的文献,使用Cochrane系统评价手册评估其偏倚风险,然后用RevMan 5.3软件对符合标准的RCT进行Meta分析。结果:文章纳入10篇文献,涉及658例患者。Meta分析结果表明,治疗组和对照组比较:总有效率高[OR=3.17,95%CI(2.01,5.00),P<0.00001],差异具有统计学意义;不良反应程度较轻,多可自行缓解。结论:单用补中益气汤或联用西药治疗AR的临床总有效率优于单用西药治疗者,两种干预措施安全性较好,但纳入的文献样本量较少,且可能存在发表性偏倚,故仍需纳入更多大样本、高质量、多中心的RCT来证实其结论。Objective To evaluate the clinical efficacy and safety of Buzhong Yiqi Decoction in the treatment of allergic rhinitis(AR).Method We searched CNKI,Wanfang,VIP,PubMed,biomedical full text database and Cochrane Library for clinical trials of Buzhong Yiqi Decoction in the treatment of AR,Since the establishment of the database,the literature retrieval time covers both Chinese and English.After screening,the risk of bias was assessed by Cochrane system evaluation manual,and then meta-analysis of RCTs that met the criteria was performed by Revman 5.3 software.Result Ten articles were included in this paper,658 patients were involved.Meta analysis showed that the total effective rate of the treatment group was higher than that of the control group[OR=3.17,95%CI(2.01,5.00),P<0.00001];The adverse reactions were mild and could be relieved by themselves.Conclusion The total effective rate of AR treated with Buzhong Yiqi Decoction alone or combined with western medicine is better than that of Western medicine alone,The safety of the two interventions was good,However,the number of included literature samples is sma ll,and there may be publication bias,so it is still necessary to include more large sample,high-quality,multi center RCT to confirm the conclusion.

关 键 词：变应性鼻炎 补中益气汤 META分析 

分 类 号：R765.21[医药卫生—耳鼻咽喉科]