小剂量阿托伐他汀钙对老年冠心病伴心力衰竭患者BNP、hs-CRP水平的影响  

Effects of low-dose atorvastatin calcium on BNP and HS-CRP indexes in elderly patients with coronary heart disease complicated by heart failure

作　　者：李菲 闫晓凡 杜宗凤 LI Fei;YAN Xiaofan;DU Zongfeng(Exhibition Road Community Health Service Center,Xicheng District,Beijing 100037,China)

机构地区：[1]北京市西城区展览路社区卫生服务中心全科,100037

出　　处：《河北医药》2021年第11期1665-1667,1671,共4页Hebei Medical Journal

摘　　要：目的探讨小剂量阿托伐他汀钙对老年冠心病伴心力衰竭患者心功能及血清脑钠肽(BNP)、超敏C-反应蛋白(hs-CRP)的影响。方法选取2018年1月至2019年10月收治的老年冠心病伴心力衰竭患者150例,按数字奇偶法分为对照组和观察组,每组75例。2组均给予常规治疗。对照组在常规治疗基础上给予阿司匹林肠溶片(100 mg,1次/d),同时给予美托洛尔(25 mg,1次/d);观察组在对照组基础上采用小剂量阿托伐他汀钙治疗(10 mg,1次/d)。2组均治疗28 d后评价临床疗效。试剂盒测定患者的血脂、血清超敏C-反应蛋白及BNP水平,心脏彩超测定患者左心室LVEF值,观察患者治疗前后心脏和运动情况的发生概率,比较2组治疗效果、心功能及BNP、hs-CRP水平。结果观察组血清总胆固醇和三酰甘油指标低于对照组,差异有统计学意义(P<0.05)。观察组治疗后LVEF、6MWD均高于对照组,差异有统计学意义(P<0.05);BNP、hs-CRP水平均低于对照组,差异有统计学意义(P<0.05),2组不良反应发生率差异无统计学意义(P>0.05)。结论小剂量阿托伐他汀钙治疗老年冠心病伴心力衰竭具有一定效果,能够改善心功能,降低血清脑钠肽、超敏C-反应蛋白的水平,可在临床上大力推广使用。Objective To investigate the effects of low-dose atorvastatin calcium on cardiac function,and serum levels of brain natriuretic peptide(BNP)and high-sensitivity C-reactive protein(hs-CRP)in elderly patients with coronary heart disease(CHD)complicated by heart failure(HF).Methods A total of 150 patients with CHD complicated by HF who were treated in our hospital from January 2018 to October 2019 were enrolled in the study,who were divided into control group and observation group according to the digital parity method,with 75 cases in each group.The patients in both groups were given conventional treatment,on this basis,the patients in control group were treated by oral aspirin enteric coated tablets(100mg,once a day),and metoprolol(25mg,once a day),however,the patients in observation group,on the basis of control group,were treated by low-dose atorvastatin calcium(10mg,once a day).After 28-day treatment,the therapeutic effects,and the serum levels of blood lipid,hs CRP and BNP as well as the left ventricular LVEF value measured by color Doppler ultrasound,and the incidence of heart and exercise conditions before and after treatment were observed and compared between the two groups.Results The serum levels of total cholesterol and triglyceride in observation group were significantly lower than those in control group(P<0.05).After treatment the levels of LVEF and 6MWD in observation group were significantly higher than those in control group(P<0.05),however,the levels of BNP and hs CRP in observation group were significantly lower than those in control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion The low-dose atorvastatin calcium in treatment of senile CHD complicated by HF has a certain therapeutic effect,which can improve heart function,reduce the serum levels of BNP and hs CRP,therefor,it is worthy of clinical application and promotion.

关 键 词：小剂量阿托伐他汀钙 老年冠心病 心力衰竭 血清脑钠肽 超敏C-反应蛋白 

分 类 号：R541.6[医药卫生—心血管疾病]