男性2型糖尿病患者血清睾酮水平同骨质疏松间的相关性分析  

Correlation Analysis between Serum Testosterone Level and Osteoporosis in Male Patients with Type 2 Diabetes

作　　者：李伟[1] 张伟[1] 吴梓琪 刘任功[1] 宋雷 张龙奎[1] LI Wei;ZHANG Wei;WU Ziqi;LIU Rengong;SONG Lei;ZHANG Longkui(The Third Department of Endocrinology,Qiqihar First Hospital,Qiqihar,Heilongjiang Province,161000 China)

机构地区：[1]齐齐哈尔市第一医院内分泌三科,黑龙江齐齐哈尔161000

出　　处：《糖尿病新世界》2021年第8期22-25,共4页Diabetes New World Magazine

基　　金：黑龙江省卫生健康委科研课题(2020-435)。

摘　　要：目的探讨男性2型糖尿病患者血清睾酮水平同骨质疏松的相关性情况,分析血清睾酮对骨代谢的影响情况。方法分析2019年8月-2020年11月于该院内分泌科进行住院治疗的男性2型糖尿病患者78例作为观察组,另选取78名血糖正常的男性健康人作为对照组。采用双能X线骨密度仪进行骨密度测量,记录患者骨密度、体质量指数(BMI)、空腹血糖(FPG),并对受试者血清睾酮(T)、N-端骨钙素(N-OC)、Ⅰ型原胶原N-端前肽(tP1NP)、β胶原降解产物(β-Crosslaps)水平进行对比。结果观察组空腹血糖(9.78±2.71)mmol/L、糖化血红蛋白(10.75±3.21)%、血清睾酮(8.89±2.37)mmol/L明显低于对照组(5.03±1.49)mmol/L、(4.97±1.31)%、(20.15±5.31)mmol/L,差异有统计学意义(t=13.565、14.724、17.102,P<0.05);观察组N-OC(23.78±5.53)ng/mL、tP1NP(23.39±6.64)ng/mL、β-Crosslaps(0.61±0.28)ng/mL水平均明显高于对照组(15.21±4.78)ng/mL、(16.36±4.98)ng/mL、(0.29±0.12)ng/mL,差异有统计学意义(t=10.355、7.480、9.277,P<0.05);睾酮与患者骨密度间呈正相关(P<0.05)。结论糖尿病患者睾酮、N-OC、tP1NP、β-Crosslaps水平均出现变化,且睾酮水平同患者骨密度间存在正相关性,为糖尿病患者骨质疏松的预防治疗提供一定的新思路。Objective To explore the correlation between serum testosterone levels and osteoporosis in male patients with type 2 diabetes,and to analyze the effect of serum testosterone on bone metabolism.Methods Analysis of 78 male patients with type 2 diabetes who were hospitalized in the endocrinology department of the hospital from August 2019 to November 2020 as the observation group,and 78 healthy men with normal blood glucose were selected as the control group.A dual-energy X-ray bone densitometer was used to measure bone density,record the patient’s bone density,body mass index(BMI),fasting blood glucose(FPG),and test the subjects’serum testosterone(T)and N-terminal osteocalcin(N-OC),typeⅠprocollagen N-terminal propeptide(tP1NP),β-collagen degradation products(β-Crosslaps)levels.Results The fasting blood glucose(9.78±2.71)mmol/L,glycosylated hemoglobin(10.75±3.21)%,and serum testosterone(8.89±2.37)mmol/L of the observation group were significantly lower than those of the control group(5.03±1.49)mmol/L,(4.97±1.31)%,(20.15±5.31)mmol/L,the difference was statistically significant(t=13.565,14.724,17.102,P<0.05);observation group N-OC(23.78±5.53)ng/mL;tP1NP(23.39±6.64)ng/mL,Β-Crosslaps(0.61±0.28)ng/mL level was significantly higher than the control group(15.21±4.78)ng/mL,(16.36±4.98)ng/mL,(0.29±0.12)ng/mL,the difference was statistically significant(t=10.355,7.480,9.277,P<0.05);there was a positive correlation between testosterone and bone mineral density(P<0.05).Conclusion Testosterone,N-OC,tP1NP,β-Crosslaps levels in diabetic patients have changed,and there is a positive correlation between testosterone levels and bone mineral density,which provides a certain new idea for the prevention and treatment of osteoporosis in diabetic patients.

关 键 词：2型糖尿病 睾酮 骨密度 N-端骨钙素 Ⅰ型原胶原N-端前肽 β胶原降解产物 

分 类 号：R587.1[医药卫生—内分泌]