血清趋化因子CCL18、CCL21水平与慢阻肺合并肺癌的相关性  

Correlation of serum chemokines CCL18 and CCL21 levels with chronic obstructive pulmonary disease combined with lung cancer

作　　者：张茜[1] 刘杰[2] 马红霞[1] ZHANG Qian;LIU Jie;MA Hong-xia(Department of Respiratory and Critical Care Medicine,Affiliated Hospital of traditional Chinese medicine of Xinjiang Medical University Urumqi,Xinjiang 830000,China;Department of Rehabilitation,the Sixth Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830002,China)

机构地区：[1]新疆医科大学附属中医医院呼吸与危重症医学科,新疆乌鲁木齐830000 [2]新疆医科大学第六附属医院康复科,新疆乌鲁木齐830002

出　　处：《临床肺科杂志》2021年第7期1004-1007,共4页Journal of Clinical Pulmonary Medicine

基　　金：新疆维吾尔自治区自然科学基金项目(No.2018D01C293)。

摘　　要：目的分析慢性阻塞性肺疾病(慢阻肺)合并肺癌患者血清CC家族趋化因子配体(CCL)18(CCL18)及CCL21与慢阻肺患者合并肺癌的关系。方法回顾性分析,收集2018年3月-2019年11月我院91例慢阻肺合并肺癌患者资料为合并组,收集同期97例慢阻肺患者资料为对照组,检测两组CCL18、CCL21水平;分析各血清指标之间的相关性及其分别与慢阻肺患者合并肺癌的关系。结果合并组CCL18、CCL21水平高于对照组(P<0.05);经相关性分析,CCL18与CCL21呈正相关(r>0,P<0.05);经二元Logistic回归分析后,建立多元回归模型,CCL18、CCL21高表达是慢阻肺合并肺癌的影响因素(OR>1,P<0.05);绘制ROC曲线,CCL18、CCL21水平预测慢阻肺患者合并肺癌风险的AUC分别为均>0.85,预测价值较好。结论慢阻肺合并肺癌患者CCL18、CCL21呈过表达,可能是慢阻肺合并肺癌的影响因素,临床可考虑通过检测慢阻肺患者血清趋化因子CCL18、CCL21水平,来预测患者合并肺癌风险,以指导合理治疗方案的制定。Objective To analyze the relationship of serum CC family chemokine ligand(CCL)18(CCL18)and CCL21 in patients with chronic obstructive pulmonary disease(COPD)combined with lung cancer.Methods A retrospective analysis was conducted,the data of 91 patients with COPD and lung cancer in our hospital from March 2018 to November 2019 were collected as the combined group,and the data of 97 patients with COPD during the same period were taken as the control group.The levels of CCL18 and CCL21 were detected in the two groups,and the correlation of serum indexes with COPD and lung cancer were analyzed.Results The levels of CCL18 and CCL21 in the combined group were higher than those in the control group(P<0.05).Through correlation analysis,the levels of CCL18 and CCL21 were positively correlated(r>0,P<0.05).After binary logistic regression analysis,multiple regression model was established,and the high expression of CCL18 and CCL21 were the influencing factors of COPD and lung cancer(OR>1,P<0.05).Then the ROC curve was drawn,the AUC of CCL18 and CCL21 predicting COPD patients with lung cancer were both>0.85,which had relatively good predictive value.Conclusion The levels of CCL 18 and CCL21 in patients with COPD and pneumonia are over-expressed,which may be the influencing factors of COPD and lung cancer.Clinically,the detection of the levels of serum chemokines CCL18 and CCL21 in COPD patients should be considered to predict the risk of patients with lung cancer and to guide a reasonable treatment plan.

关 键 词：慢性阻塞性肺疾病 肺癌 CC家族趋化因子配体18 CC家族趋化因子配体21 相关性 

分 类 号：R563.9[医药卫生—呼吸系统] R734.2[医药卫生—内科学]