养阴散结法联合替考拉宁对肝硬化顽固性腹水腹腔感染患者的临床疗效  

Clinical effects of Nourishing Yin and Eliminating Stagnation Method combined with teicoplanin on patients with abdominal cavity infection due to liver cirrhosis and refractory ascites

作　　者：穆怀博[1] 张延方[1] 初冬梅[1] 芦秋彤 肖旭[2] 曲宝亮[1] MU Huai-bo;ZHANG Yan-fang;CHU Dong-mei;LU Qiu-tong;XIAO Xu;QU Bao-liang(Department of Pharmacy,Chengde Municipal Central Hospital,Chengde 067000,China;Department of Clinical Pharmacy,The Hospital Affiliated to Chengde Medical College,Chengde 067000,China)

机构地区：[1]承德市中心医院药剂科,河北承德067000 [2]承德医学院附属医院临床药学部,河北承德067000

出　　处：《中成药》2021年第6期1471-1475,共5页Chinese Traditional Patent Medicine

基　　金：河北省中医药管理局科研计划项目(2015241)。

摘　　要：目的考察养阴散结法联合替考拉宁对肝硬化顽固性腹水腹腔感染患者的临床疗效。方法 86例患者随机分为对照组和观察组,每组43例,对照组给予替考拉宁,观察组在对照组基础上加用养阴散结法,疗程2周。检测细菌清除率、症状缓解用时、肝功能指标(TBIL、AST、ALT)、肝纤维化指标(Ⅳ-C、LN、HA、PCⅢ)、炎性因子(IL-2、IL-6、IL-10、TNF-α)、不良反应发生率变化。结果观察组症状缓解用时短于对照组(P<0.05)。治疗后,2组肝功能指标、肝纤维化指标、IL-6、TNF-α降低(P<0.05),IL-2、IL-10升高(P<0.05),以观察组更明显(P<0.05)。2组细菌清除率、不良反应发生率比较,差异无统计学意义(P>0.05)。结论养阴散结法联合替考拉宁可安全有效地减轻肝硬化顽固性腹水腹腔感染患者炎症反应,改善肝功能和临床症状,抑制肝纤维化进程。AIM To investigate the clinical effects of Nourishing Yin and Eliminating Stagnation Method combined with teicoplanin on patients with abdominal cavity infection due to liver cirrhosis and refractory ascites.METHODS Eighty-six patients were randomly assigned into control group(43 cases)for 2-week administration of teicoplanin,and observation group(43 cases)for 2-week administration of both Nourishing Yin and Eliminating Stagnation Method and teicoplanin.The changes in rate of bacterial clearance,time for symptom relief,liver function indices(TBIL,AST,ALT),liver fibrosis indices(IV-C,LN,HA,PCⅢ),inflammatory factors(IL-2,IL-6,IL-10,TNF-α),and incidence of adverse reactions were detected.RESULTS The observation group demonstrated shorter time for symptom relief than the control group(P<0.05).After the treatment,the two groups displayed decreased liver function indices,liver fibrosis indices,IL-6 and TNF-α(P<0.05),and increased IL-2 and IL-10(P<0.05),especially for the observation group(P<0.05).No obvious differences in rate of bacterial clearance and incidence of adverse reactions were observed(P>0.05).CONCLUSION For the patients with abdominal cavity infection due to liver cirrhosis and refractory ascites,Nourishing Yin and Eliminating Stagnation Method combined with teicoplanin can safely and effectively alleviate inflammatory responses,improve liver functions and clinical symptoms,and inhibit the process of liver fibrosis.

关 键 词：养阴散结法 替考拉宁 肝硬化 顽固性腹水 腹腔感染 

分 类 号：R287[医药卫生—中药学]