滇黄芩根化学成分的研究  

Chemical constituents from the roots of Scutellaria amoena

作　　者：付胜男 李欣坪 王蒙蒙 方琼莲 潘蕊 林玉萍 FU Sheng-nan;LI Xin-ping;WANG Meng-meng;FANG Qiong-lian;PAN Rui;LIN Yu-ping(School of Chinese Materia Medica,Yunnan University of Chinese Medicine,Kunming 650500,China)

机构地区：[1]云南中医药大学中药学院,云南昆明650500

出　　处：《中成药》2021年第6期1493-1499,共7页Chinese Traditional Patent Medicine

基　　金：云南省科学技术厅云南中医学院应用基础研究联合专项[2017FF117(-022)];2019年云南中医药大学大学生创新项目(2019)。

摘　　要：目的研究滇黄芩Scutellaria amoena C.H.Wright根的化学成分。方法滇黄芩根90%乙醇提取物的分析采用硅胶、Sephadex LH-20、重结晶进行分离纯化,根据理化性质及波谱数据鉴定所得化合物的结构。结果从中得到20个化合物,分别鉴定为黄芩素(1)、黄芩苷(2)、千层纸素A(3)、千层纸素A-7-O-β-D-吡喃葡萄糖醛酸苷(4)、千层纸素A-7-O-β-D-吡喃葡萄糖醛酸苷甲酯(5)、千层纸素A-7-O-β-D-吡喃葡萄糖醛酸苷乙酯(6)、汉黄芩素(7)、汉黄芩素-7-O-β-D-吡喃葡萄糖醛酸苷甲酯(8)、去甲汉黄芩素(9)、去甲汉黄芩素-7-O-β-D-吡喃葡萄糖醛酸苷甲酯(10)、白杨素(11)、白杨素-7-O-β-D-吡喃葡萄糖醛酸苷(12)、白杨素-7-O-β-D-吡喃葡萄糖醛酸苷甲酯(13)、5,7,2′-三羟基-6-甲氧基黄酮(14)、韧黄芩素Ⅱ-7-O-β-D-吡喃葡萄糖醛酸苷(15)、韧黄芩素Ⅱ-2′-O-β-D-吡喃葡萄糖醛酸苷(16)、高车前素(17)、亚油酸(18)、韧黄芩素Ⅱ-7-O-β-D-吡喃葡萄糖醛酸苷甲酯(19)、韧黄芩素Ⅱ-2′-O-β-D-吡喃葡萄糖苷(20)。结论化合物5、8、10、13、15~18为首次从该植物中分离得到。AIM To study the chemical constituents from the roots of Scutellaria amoena C.H.Wright.METHODS The 90%ethanol extract from the roots of S.amoena was isolated and purified by silica,Sephadex LH-20 and recrystallization,then the structures of obtained compounds were identified by physicochemical properties and spectral data.RESULTS Twenty compounds were isolated and identified as baicalein(1),baicalin(2),oroxylin A(3),oroxylin A-7-O-β-D-glucurunopyranoside(4),oroxylin A-7-O-β-D-glucopyranoside 6″-methyl ester(5),oroxylin A-7-O-β-D-glucopyranoside 6″-ethyl ester(6),wogonin(7),wogonin-7-O-β-D-glucopyranoside 6″-methyl ester(8),norwogonin(9),norwogonin-7-O-β-D-glucopyranoside 6″-methyl ester(10),chrysin(11),chrysin-7-O-β-D-glucurunopyranoside(12),chrysin-7-O-β-D-glucopyranoside 6″-methyl ester(13),5,7,2′-trihydroxy-6-methoxy-flavone(14),tenaxinⅡ-7-O-β-D-glucuronopyranoside(15),texaxinⅡ-2′-O-β-D-glucopyranoside(16),hispidulin(17),linoleic acid(18),tenaxinⅡ-2′-O-β-D-glucopyranoside(19),tenaxinⅡ-7-O-β-D-glucuronopyranoside 6″-methyl ester(20).CONCLUSION Compounds 5,8,10,13,15-18 are isolated from this plant for the first time.

关 键 词：滇黄芩 根 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]