Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils  

作　　者：Yiyun Gao Yan Gao Yuanfu Ding Huaping Tan Aihua Zou Shengke Li 

机构地区：[1]School of Materials Science and Engineering,Nanjing University of Science and Technology,Nanjing 210094,China [2]Shanghai Key Laboratory of Functional Materials Chemistry,State Key Laboratory of Bioreactor Engineering and Institute of Applied Chemistry,School of Chemistry and Molecular Engineering,East China University of Science and Technology,Shanghai 200237,China [3]State Key Laboratory of Quality Research in Chinese Medicine.Institute of Chinese Medical Sciences.University of Macao.Macao.China [4]College of Chemistry and Materials Science,Shanghai Normal University.Shanghai 200234,China

出　　处：《Chinese Chemical Letters》2021年第3期949-953,共5页中国化学快报（英文版）

基　　金：supported by the National Natural Science Foundation of China(No.201872051);National Key Research and Development Plan(No.2017YFD0200306);Startup Research Fund of Nanjing University of Science and Technology(No.AE89991/163)。

摘　　要：With excellent biocompatibility and biodegradability,natural polysaccharides and their derivative s have exhibited great potential in constructing drug delivery ve hicles for tissue engineering and therapeutics.Cucurbit[n]uril(CB[n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuliresponsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-re sponsive drug release by incorpo ration with other stimuli including photo,redox,and enzyme.Through host-guest interactions between CB[6]and aliphatic diamines,functional tags covalently connected with CB[6]can be readily anchored into polysaccharidebased hydrogels,realizing multiple functionalization.The rheological prope rty and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB[8]-mediated dyna mic homo or hetero crosslinking of polysaccharides and/or other polymers.In this review,we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB[6]and CB[8],covering both bulk hydrogels and particular systems.At the end,possible utilization of CB[7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed.

关 键 词：Cucurbit[n]uril Host-guest interaction POLYSACCHARIDES Hydrogel Drug delivery Tissue engineering 

分 类 号：TQ317[化学工程—高聚物工业] TQ460.4