Three new decarbonyl prenylphloroglucinols bearing unusual spirost subunits from Hypericum scabrum and their neuronal activities  

作　　者：Jie Ma Guiyang Xia Yingda Zang Chuangjun Li Jianbo Yang Jiwu Huang Jianjun Zhang Yalun Su Aiguo Wang Dongming Zhang 

机构地区：[1]State Key Laboratory of Bioactive Substance and Function of Natural Medicines,Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China [2]Key Laboratory of Chinese Internal Medicine of Ministry of Education and Beijing,Dongzhimen Hospital,Beijing University of Chinese Medicine,Beijing 100700,China

出　　处：《Chinese Chemical Letters》2021年第3期1173-1176,共4页中国化学快报（英文版）

基　　金：supported by the Beijing Natural Science Foundation(No.7194299);Fundamental Research Funds for the Central Universities(No.3332018089);the CAMS Innovation Fund for Medical Sciences(No.2016-I2M-1-010);the Drug Innovation Major Project(No.2018ZX09711001-002-010,2018ZX09735006)。

摘　　要：Three novel polycyclic polyprenyled acylphloroglucinols,Hyperscabins A-C,were obtained from the aerial parts of Hypericum scabrum.They featured an unprecedented 5,5-spiro ketal subunit with the loss of C-2’carbonyl in the phloroglucinol ring.Their structures were characterized by extensive spectroscopic analyses,NMR calculations with DP4+analysis,calculated electronic circular dichroism(ECD)spectra and the application of modified Mosher’s methods.In the assay of[^(3)H]-5-HT and[^(3)H]-NE reuptake inhibition,compounds 1 and 2 showed good inhibito ry activity(81.8%and 83.2%)in 10μmol/L.In addition,compound 1 significantly increased cell viability in the experiment of oxygen and glucose deprivation/deoxygenation.

关 键 词：Hypericum scabrum Prenylphloroglucinols Decarbonyl 5 5-Spiroketal Neuronal effect 

分 类 号：TQ460.1[化学工程—制药化工]