Nickel(Ⅱ)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions with carboxylic acid derivatives  

作　　者：Pengbo Ye Xuan Liu Gang Wang Lei Liu 

机构地区：[1]School of Chemistry and Chemical Engineering,Shandong University,Ji'nan 250100,China

出　　处：《Chinese Chemical Letters》2021年第3期1237-1240,共4页中国化学快报（英文版）

基　　金：financial supported by the Natural Science Foundation of China(Nos.21722204,21971148);Fok Ying Tung Education Foundation(No.151035)。

摘　　要：A nickel(Ⅱ)-catalyzed asymmetric alkylation of acyclic oxocarbenium ions generated in situ from corresponding acetals with carboxylic acid derivatives to prepareβ-alkoxyl carbonyl moieties with diverseα-substituents has been disclosed.The method exhibited broad scope of acetals and carboxylic acid derivatives with excellent enantioselectivity and good functional group compatibility,and can be conducted in a gram-scale without obvious loss of efficiency.

关 键 词：Oxocarbenium ion ACYCLIC NICKEL Asymmetric catalysis ALKYLATION 

分 类 号：O621.251[理学—有机化学]