miR-101、miR-122在妊娠期糖尿病患者血清和胎盘组织中表达及意义  

Expression and significance of serum and placental miR-101 and miR-122 in patients with gestational diabetes mellitus

作　　者：陈丽霞 张秀薇[1] 禤文婷[1] 尹镇钊[1] 陈松锦[1] CHEN Li-xia;ZHANG Xiu-wei;XUAN Wen-ting;YIN Zhen-zhao;CHEN Song-jin(Department of Endocrinology,Dongguan People's Hospital,Dongguan 523000,China)

机构地区：[1]广东省东莞市人民医院内分泌科,广东东莞523000

出　　处：《广东医科大学学报》2021年第3期267-270,共4页Journal of Guangdong Medical University

基　　金：广东省医学科学技术研究基金项目(No.C2018053)。

摘　　要：目的探讨miR-101、miR-122在妊娠期糖尿病(GDM)患者血清和胎盘组织中表达及意义。方法采用实时荧光定量PCR检测42例GDM孕妇(观察组)、30例健康孕妇(对照组)血清和胎盘组织中miR-101、miR-122水平,并分析血清miR-101、miR-122与GDM孕妇临床、胰岛素抵抗相关性。结果观察组血清和胎盘组织中miR-101、miR-122水平明显高于对照组(P<0.01)。血清miR-101水平与空腹血糖(FBG)呈正相关,但与空腹胰岛素(FINS)、胰岛素抵抗指数(HOMA-IS)呈负相关(P<0.05);miR-122水平与FBG、胰岛素分泌指数(HOMA-IR)呈正相关,但与FINS呈负相关(P<0.05)。结论GDM患者血清与胎盘组织中miR-101与miR-122表达增高,且与胰岛素抵抗具有相关性。Objective To investigate the expression and significance of serum and placental miR-101 and miR-122 in patients with gestational diabetes mellitus(GDM).Methods Serum and placental miR-101 and miR-122 levels in 42 GDM(observation group)and 30 healthy pregnant women(control group)were detected by qRT-PCR,and their correlations with clinical/insulin resistance parameters in GDM women were analyzed.Results Serum and placental miR-101 and miR-122 levels were higher in observation group than in control group(P<0.01).Serum miR-101 content was positively correlated with fasting blood glucose(FBG)but negatively with fasting insulin(FINS)and HOMA-IS(P<0.05).Serum miR-122 level was positively correlated with FBG and HOMA-IR but negatively with FINS(P<0.05).Conclusion Serum and placental miR-101 and miR-122 levels are increased and correlated with insulin resistance parameters in GDM women.

关 键 词：MIRNA 妊娠期糖尿病 胎盘 胰岛素抵抗 

分 类 号：R714.25[医药卫生—妇产科学]