血脂、总胆红素、尿酸及超敏C反应蛋白联合检测在冠心病诊断中的应用价值  

Application of combined detection of blood lipids,total bilirubin,uric acid and hypersensitive c-reactive protein in diagnosis of coronary heart disease

作　　者：许坚锋[1] 钟志娟[2] 郭国威[1] 李慎果[1] 魏涛[1] XU Jian-feng;ZHONG Zhi-juan;GUO Guo-wei;LI Shen-guo;WEI Tao(Zhuhai Hospital,Guangdong Provincial Hospital of Traditional Chinese Medicine;Fifth Affiliated Hospital of Sun Yat-sen University,Zhuhai 519000,China)

机构地区：[1]广东省中医院珠海医院 [2]中山大学附属第五医院,广东珠海519000

出　　处：《广东医科大学学报》2021年第3期287-290,共4页Journal of Guangdong Medical University

基　　金：珠海市科技计划医疗卫生项目(No.20181117B020017)。

摘　　要：目的了解联合检测血脂、总胆红素(TBil)、尿酸(UA)及超敏C反应蛋白(hs-CRP)对冠状动脉粥样硬化性心脏病(CHD)的诊断价值。方法检测80例CHD(试验组)、80例健康体检者(对照组)血脂、TBil、UA、hs-CRP水平,应用受试者工作特征曲线(ROC曲线)比较各指标联合检测时的灵敏度、特异度及ROC曲线下面积(AUC)的差异。结果CHD组血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)、UA及hs-CRP水平高于对照组,高密度脂蛋白胆固醇(HDL-C)、TBil水平则低于对照组(P<0.01或0.05)。血脂4项联合检测的AUC和灵敏度明显高于单项检测;TG-HDL-LDL-UA-TBil-hs-CRP联合检测的灵敏度最高。结论血脂、TBil、UA、hs-CRP联合检测的诊断效能明显高于单项检测,可作为CHD危险性指标。Objective To evaluate the diagnostic value of combined detection of blood lipids,total bilirubin(TBil),uric acid(UA)and hypersensitive c-reactive protein(hs-CRP)on coronary heart disease(CHD).Methods Blood lipids,TBil,UA and hs-CRP levels were determined in 80 CHD patients(experimental group)and 80 healthy controls(control group).Sensitivity,specificity,and area under ROC curve(AUC)of each parameter were compared.Results Compared with control group,total cholesterol(TC),triglyceride(TG),low density lipoprotein cholesterol(LDL-C)、UA and hs-CRP levels were higher,while high-density lipoprotein cholesterol(HDL-C)and TBil were lower in experimental group(P<0.01 or 0.05).AUC and sensitivity of combined detection of 4 serum lipid indexes were higher than those of single index.Combined detection of TG,HDL-C,LDL-C,UA,TBil,and hs-CRP was the most sensitive.Conclusion The diagnostic efficacy of combined detection of serum lipids,TBil,UA and hs-CRP is superior to that of single index,which could be risk parameters for CHD.

关 键 词：冠心病 血脂 胆红素 尿酸 超敏C反应蛋白 

分 类 号：R446[医药卫生—诊断学] R541[医药卫生—临床医学]