孕早期血清维生素D水平与妊娠期高血压疾病发病风险的关系  

Relationship between serum vitamin D level and hypertensive disorder complicating pregnancy in early pregnancy

作　　者：徐婉卿 黄锡欢[1] 尚雪[1] XUWan-qing;HUANG Xi-huan;SHANG Xue(Department of Obstetrics,Bo'ai Hospital,Zhongshan 528400,China)

机构地区：[1]广东省中山市博爱医院产科,广东中山528400

出　　处：《广东医科大学学报》2021年第3期298-300,共3页Journal of Guangdong Medical University

摘　　要：目的探究孕早期维生素D(VD)水平与妊娠期高血压疾病(HDCP)发病风险的关系。方法 162例早期孕妇根据孕检结果分为妊娠正常组(n=80)和妊娠异常组(n=82),后组又分为妊娠期高血压组(n=30)、轻度子痫前期组(n=29)和重度子痫前期组(n=23);比较各组血清VD、钙及磷水平,并分析VD与HDCP相关性。结果妊娠异常组血清VD、钙水平明显低于妊娠正常组,而磷水平高于妊娠正常组(P<0.01)。重度子痫前期组血清VD、钙水平显著低于妊娠高血压组和轻度子痫前期组(P<0.01),而磷水平差异无统计学意义(P>0.05)。血清VD水平与HDCP发生风险呈显著负相关(r=-0.846,P<0.01)。结论 HDCP早期孕妇血清VD水平明显降低,孕早期补充VD可降低HDCP发生风险。Objective To investigate the relationship between serum vitamin D(VD) level hypertensive disorder complicating pregnancy(HDCP) in early pregnancy. Methods Based on the antenatal examination, 162 early pregnancy womenwere divided into normal(n=80) and abnormal(n=82) pregnancy groups, of which the latter included 30 gestational hypertension, 29 mild and 23 severe preeclampsia cases. Serum levels of VD, calcium and phosphorus were compared among all groups, and correlation between VD and HDCP was also analyzed. Results Serum VD and calcium levels were lower but phosphorus content was higher in abnormal pregnancy group compared with in normal pregnancy group( P <0.01).Serum VD and calcium levels were lower in severe preeclampsia than in gestational hypertension and mild preeclampsia group(P<0.01), while serum phosphorus content was comparable among 3 groups( P > 0.05). Serum VD level was negatively correlated with HDCP(r=-0.846, P<0.01). Conclusion There is a decreased serum VD level in early pregnancy women with HDCP. VD supplementation may reduce the risk of HDCP in early pregnancy.

关 键 词：孕早期 维生素D 妊娠期高血压 

分 类 号：R714[医药卫生—妇产科学]