不同剂量来曲唑联合促性腺激素治疗克罗米芬抵抗多囊卵巢综合征的临床观察  

Combined gonadotropin and different doses of letrozole in clomiphene-resistant polycystic ovary syndrome

作　　者：杨冬[1] 王丽峰[1] 张颖 温都苏[1] YANG Dong;WANG Li-feng;ZHANG Ying;WEN du-su(Department of Gynecology,Lianjiang People's Hospital,Lianjiang 524400,China;Department of Gynecology and Obstetrics,Affiliated Hospital of Guangdong Medical University,Zhanjiang 524023,China)

机构地区：[1]广东省廉江市人民医院妇科,广东廉江524400 [2]广东医科大学附属医院妇产科,广东湛江524023

出　　处：《广东医科大学学报》2021年第3期321-324,共4页Journal of Guangdong Medical University

基　　金：湛江市科技计划项目(No.2017B01081)。

摘　　要：目的观察不同剂量来曲唑联合促性腺激素治疗克罗米芬抵抗多囊卵巢综合征(PCOS)的效果。方法135例克罗米芬抵抗PCOS患者随机分为A、B、C组,分别给予来曲唑2.5 mg/d、5.0 mg/d、20 mg顿服联合促性腺激素治疗。比较3组疗效、性激素水平、促排卵效果和不良反应。结果B、C组疗效、血清雄激素(LH、E2、FSH)水平、优势卵泡数目、妊娠率高于A组,而卵泡成熟时间、成熟卵泡直径及促性腺激素用量少于A组(P<0.01或0.05)。结论20 mg来曲唑顿服联合促性腺激素治疗克罗米芬抵抗PCOS促排卵效果较好,可提高妊娠率。Objective To observe the clinical efficacy of combined gonadotropin and different doses of letrozole in clomiphene-resistant polycystic ovary syndrome(PCOS).Methods A total of 135 patients with clomiphene-resistant PCOS were randomly treated with 2.5 mg/d letrozole plus gonadotropin(group A),5.0 mg/d letrozole plus gonadotropin(group B)or single dose of 20 mg letrozole plus gonadotropin(group C).Clinical efficacy,serum levels of sex hormones,ovulation induction and adverse reactions were compared among 3 groups.Results Compared with group A,clinical efficacy,serum levels of sex hormones(LH、E2、FSH),dominant follicles,and pregnancy rate were higher,while follicular maturation time,mature follicle diameter,and gonadotropin usage were lower in groups B and C(P<0.01 or 0.05).Conclusion Single dose of 20 mg letrozole plus gonadotropin can improve ovulation induction and pregnancy rate in patients with clomiphene-resistant PCOS.

关 键 词：多囊卵巢综合征 克罗米芬 来曲唑 促性腺激素 

分 类 号：R711.6[医药卫生—妇产科学]