不孕不育患者血清AMH、FSH、LH、E2水平的表达及其与卵巢功能的相关性  

Expression of serum AMH,FSH,LH and E2 and their relevance to ovarian function in infertile women

作　　者：吴少珍[1] 杨海霞[1] 官燕飞[1] 叶贵诚[1] 程立子[2] WU Shao-zhen;YANG Hai-xia;GUAN Yan-fei;YE Gui-cheng;CHENG Li-zi(Clinical Laboratory,Boai Hospital of Zhongshan,Zhongshan 528403,China;Reproductive Center,Boai Hospital of Zhongshan,Zhongshan 528403,China)

机构地区：[1]广东省中山市博爱医院检验科,广东中山528403 [2]广东省中山市博爱医院生殖中心,广东中山528403

出　　处：《广东医科大学学报》2021年第3期338-340,共3页Journal of Guangdong Medical University

摘　　要：目的了解不孕不育患者血清抗苗勒氏管激素(AMH)、促卵泡刺激素(FSH)、促黄体生成素(LH)、雌二醇(E2)水平的表达及其与卵巢功能的相关性。方法选取198例不孕症患者,根据患者卵巢功能分为卵巢功能正常组和卵巢功能异常组,同时选取同期84例体检健康女性作为对照组。比较3组血清AMH、FSH、LH和E2水平,并分析指标与卵巢功能的相关性。结果卵巢功能异常组的E2、FSH、LH水平低于卵巢功能正常组和对照组,AMH水平则高于其他两组(P<0.01)。卵巢功能正常组的各项指标与对照组比较差异无统计学意义(P>0.05)。E2、LH、FSH与卵巢功能呈正相关(r分别为0.205、0.236、0.240,均P<0.05);AMH与卵巢功能呈负相关(r=-0.215,P<0.05)。结论血清AMH、FSH、LH、E2的表达与不育不孕患者卵巢功能有关,对辅助生殖技术检查具有重要的价值。Objective To investigate the Expression of serum Antimullerian Hormone(AMH), Lutropin Alfa Hormone(FSH), Luteinizing hormone(LH) and Estradiol(E2) and their relevance to ovarian function in infertile women. Methods A total of 198 infertile women were divided into the Normal Group and Abnormal Group according to their ovarian function,and 84 healthy women in the same period were selected as the Control Group. The levels of serum AMH, FSH, LH and E2 were compared among the three groups. Results The Abnormal Group had the serum E2, FSH and LH levels lower than the Normal Group and Control Group, but had the serum AMH level higher than the two groups(P<0.01). There was no statistical difference in various indicators between the Normal Group and the Control Group(P>0.05). E2, LH and FSH were positively correlated with ovarian function(r=0.205, 0.236, and 0.240, respectively, P<0.05 for all). AMH was negatively correlated with ovarian function(r=-0.215,P<0.05). Conclusion AMH, FSH, LH and E2 are correlated with ovarian function of infertile women and can of great value to the assisted reproductive technology.

关 键 词：不孕不育 卵巢功能 抗苗勒氏管激素 雌二醇 促卵泡刺激素 

分 类 号：R446.1[医药卫生—诊断学]