恩替卡韦联合双歧杆菌四联活菌片对乙型病毒性肝炎肝硬化患者肠道微生态及乙肝病毒标志物的影响  

Effects of entecavir combined with bifidobacterium tetravaccine tablets on intestinal microecology and hepatitis B virus markers in patients with viral hepatitis type B and liver cirrhosis

作　　者：王乐 孟亚峰 WANG Le;MENG Yafeng(Hanzhong Second People's Hospital,Hanzhong 723000,China)

机构地区：[1]汉中市第二人民医院,陕西汉中723000

出　　处：《临床医学研究与实践》2021年第18期70-72,共3页Clinical Research and Practice

摘　　要：目的探讨恩替卡韦联合双歧杆菌四联活菌片对乙型病毒性肝炎(简称乙肝)肝硬化患者肠道微生态及乙肝病毒标志物(HBVM)的影响。方法选取2018年1月至2020年1月我院收治的60例乙肝肝硬化患者作为研究对象,根据随机数字表法将其分为对照组(n=30,恩替卡韦)及观察组(n=30,恩替卡韦联合双歧杆菌四联活菌片)。比较两组的临床效果。结果治疗后,两组的双歧杆菌、乳酸杆菌数目均增多,肠杆菌、肠球菌数目均减少,且观察组优于对照组(P<0.05)。观察组的HBV-DNA、HBeAg阴转率及HBeAg/HBeAb血清转换率均高于对照组(P<0.05)。治疗后,两组的HA、LN、PCⅢ水平均降低,且观察组低于对照组(P<0.05)。结论恩替卡韦联合双歧杆菌四联活菌片治疗乙肝肝硬化患者的效果显著,可有效调节患者的肠道微生态,提升HBV-DNA、HBeAg阴转率,降低血清肝纤维化指标水平,值得临床推广应用。Objective To explore the effects of entecavir combined with bifidobacterium tetravaccine tablets on intestinal microecology and hepatitis B virus markers(HBVM)in patients with viral hepatitis type B and liver cirrhosis.Methods A total of 60 patients with viral hepatitis type B and liver cirrhosis admitted in our hospital from January 2018 to January 2020 were selected as the research objects,and the patients were divided into control group(n=30,entecavir)and observation group(n=30,entecavir combined with bifidobacterium tetravaccine tablets)according to the random number table method.The clinical effects of the two groups were compared.Results After treatment,the number of Bifidobacterium and Lactobacillus in the two groups increased,and the number of Enterobacter and Enterococcus decreased,and those in the observation group were better than the control group(P<0.05).The negative conversion rate of HBV-DNA and HBeAg,HBeAg/HBeAb serum conversion rate in the observation group were higher than those in the control group(P<0.05).After treatment,the levels of HA,LN and PCⅢin the two groups decreased,and those in the observation group were lower than the control group(P<0.05).Conclusion Entecavir combined with bifidobacterium tetravaccine tablets in the treatment of patients with viral hepatitis type B and liver cirrhosis has a significant effect,it can effectively regulate the intestinal microecology of patients,improve the negative conversion rate of HBV-DNA and HBeAg,and reduce the level of serum liver fibrosis index,which is worthy of clinical promotion and application.

关 键 词：恩替卡韦 双歧杆菌四联活菌片 乙型病毒性肝炎 肝硬化 肠道微生态 

分 类 号：R512.62[医药卫生—内科学]