LncRNAs与血管疾病发生机制关系研究进展  

Research progress on correlation between lncRNAs and pathogenesis of vascular diseases

作　　者：严茂胜[1] 方森洲 张丹英[1] 徐国勇[1] 林欣琪 晏华[1] YAN Mao-sheng;FANG Sen-zhou;ZHANG Dan-ying;XU Guo-yong;LIN Xin-qi;YAN Hua(Guangdong Province Hospital for Occupational Disease Prevention and Treatment,Guangdong Provincial Key Laboratory of Occupational Disease Prevention and Treatment,Guangzhou,Guangdong 510300,China)

机构地区：[1]广东省职业病防治院,广东省职业病防治重点实验室,广东广州510300 [2]广州医科大学,广东广州511436

出　　处：《中国职业医学》2021年第1期103-106,共4页China Occupational Medicine

基　　金：广东省自然科学基金(2018A030313955);广东省医学科研基金(A2018360,A2019388);广东省职业病防治重点实验室(2017B030314152);广州市科技计划项目(201804010099);海珠区科技计划项目(海科工商信计2018-90)。

摘　　要：职业性手臂振动病(HAVD)是我国的法定职业病,振动性血管损伤是其发病的重要机制。HAVD一旦发生较难恢复,对手传振动作业工人造成巨大伤害,但现有技术,较难早期发现和评估其发生和进展,不利于疾病的早期预防和治疗。长链非编码核糖核酸(lncRNAs)在调节血管的发育、生长和重塑等生物过程有重要作用。本文对lncRNAs在血管损伤中作用及机制进行综述,为HAVD早期诊断和治疗研究提供科学理论依据。Occupational hand-arm vibration diseases(HAVD) is a legitimate occupational disease in China, and the mechanism of its pathogenesis is vibration-induced vascular injury. Once HAVD occurs, it is difficult for the patients to recover and can cause great harm to workers exposed to hand-arm vibration. It is difficult to detect and evaluate the occurrence and progress of the disease at an early stage using existing technology, which is disadvantageous to the early prevention and treatment of the disease. Long noncoding RNAs(lncRNAs) play an important role in regulating the development, growth, and remodeling of blood vessels and other biological processes. This article reviews the role and mechanism of lncRNAs in vascular injury, and provides scientific theoretical basis for early diagnosis and treatment of HAVD.

关 键 词：lncRNAs 内皮细胞 血管平滑肌细胞 血管新生 生物标志物 手臂振动病 研究进展 

分 类 号：R135.4[医药卫生—劳动卫生]