严重烧创伤感染及其并发症的免疫新认识  

New understanding on the immunity for severe infections and complications in burns and trauma

作　　者：姚咏明[1] 栾樱译[1] Yao Yongming;Luan Yingyi(Translational Medicine Research Center,Medical Innovation Research Division and the Fourth Medical Center of PLA General Hospital,Beijing 100048,China)

机构地区：[1]解放军总医院第四医学中心、医学创新研究部转化医学研究中心,北京100048

出　　处：《中华烧伤杂志》2021年第6期519-523,共5页Chinese Journal of Burns

基　　金：国家自然科学基金重点项目(81730057);国家自然科学基金面上项目(81873943);军事医学创新工程重点项目(18CXZ026,BLJ18J006)。

摘　　要：烧创伤感染发生机制复杂,涉及炎症失控、免疫紊乱、凝血异常及机体多系统、多器官病理生理改变。尽管积极处理原发病、抗菌药物应用和器官支持治疗仍然是烧创伤感染处理的基础,但免疫调理为烧创伤感染及其并发症的干预开辟了新方向。深入了解其炎症免疫反应及其调控机制,探索新的预警生物标志物和免疫防治策略,对提高临床烧创伤感染的救治水平和改善患者预后具有重要意义。The mechanisms of burn/trauma related infection are complicated,involving uncontrolled inflammation,immune disorder,coagulation abnormality,and pathophysiological changes of multiple systems or organs.Although active management of primary diseases,application of antibiotics,and organ support treatment are the basis for the management of burn/trauma related infection,immune modulation opens up a new direction for the intervention of burn/trauma related infection and the relevant complications.In-depth understanding of inflammation-immune response and its regulatory mechanisms,and exploring new early warning biomarkers and immune interventional strategies are of great significance for improving the level of treatment of clinical burn/trauma related infections and improving the prognosis of patients.

关 键 词：烧伤 感染 免疫调节 治疗应用 并发症 

分 类 号：R28[医药卫生—中药学] Q26[医药卫生—中医学]