机械张力对创伤后增生性瘢痕形成的影响研究进展  

Research advances on the effect of mechanical tension in post-traumatic hypertrophic scar formation

作　　者：赵倩楠 周粤闽 孙朝阳 Zhao Qiannan;Zhou Yuemin;Sun Chaoyang(Department of Plastic and Reconstructive Surgery,Huaihe Hospital,Henan University,Kaifeng 475000,China)

机构地区：[1]河南大学淮河医院整形修复外科,开封475000

出　　处：《中华烧伤杂志》2021年第6期586-590,共5页Chinese Journal of Burns

基　　金：河南省科技发展计划(172102410005);河南省医学科技攻关计划(201401014);河南大学研究生“英才计划”(SYL18060140)。

摘　　要：创伤导致的瘢痕不但影响患者外观及功能,还会不同程度影响患者心理健康状况及生活质量。目前已有学者通过基础研究证实,机械张力通过各种机械转导通路促进炎症细胞、成纤维细胞等细胞增殖及血管生成和上皮形成,在增生性瘢痕形成中发挥重要作用。临床研究证实,采取降低创面机械张力的手术和辅助治疗可促进创面愈合、抑制瘢痕增生。本文总结了增生性瘢痕形成的机制及降低创伤创面机械张力的手术方式和辅助手段,以期为临床减少增生性瘢痕形成提供依据。Traumatic scar can not only exert influence on appearance and function of patients,but also affect psychological health status and life quality of patients to varying degrees.At present,scholars have confirmed from basic research that mechanical tension promotes the proliferation of inflammatory cells,fibroblasts,and other cells,as well as angiogenesis and epithelialization through a variety of mechanical conduction pathways and plays an important role in the formation of hypertrophic scar.Clinical studies have confirmed that surgical methods and adjuvant treatment to reduce the mechanical tension on wound can promote wound healing and inhibit hyperplasia of scar.This article summarizes the mechanism of hypertrophic scar formation,and surgical methods and adjunct means of reducing mechanical tension in traumatic wounds,aiming to provide a reference for reducing formation of hypertrophic scar in clinics.

关 键 词：创伤和损伤 瘢痕 机械张力 减张治疗 辅助干预 

分 类 号：R644[医药卫生—外科学] G237.5[医药卫生—临床医学] G211[文化科学]