新疆维吾尔自治区10684例肾活检病理资料与流行病学特点分析  

Analysis of pathological data and epidemiological characteristics of 10 684 cases of renal biopsy in Xinjiang Uygur Autonomous Region

作　　者：段严雅 列才华 张蕾[3] 阿依加肯·卡司木马力 郭雯 李勇[6] 姜鸿[1] 陆晨[1] Duan Yanya;Lie Caihua;Zhang Lei;Ayijiaken Kasimumali;Guo Wen;Li Yong;Jiang Hong;Lu Chen(Department of Nephrology,People's Hospital of Xinjiang Uygur Autonomous Region,Urumqi 830000,China;Department of Nephrology,Xinjiang Military General Hospital,Urumqi 830000,China;Department of Nephrology,the Fifth Affiliated Hospital of Xinjiang Medical University,Urumqi 830000,China;Department of Nephrology,Kashgar Prefecture Second People's Hospital of Xinjiang Uygur Autonomous Region,Kashgar City of Xinjiang Uygur Autonomous Region 844000,China;Department of Nephrology,Xinhua Hospital of Yili Prefecture,Xinjiang Uygur Autonomous Region,Yining City of Xinjiang Uygur Autonomous Region 835100,China;Department of Nephrology,Aksu First People's Hospital of Xinjiang Uygur Autonomous Region,Aksu City of Xinjiang Uygur Autonomous Region 843000,China)

机构地区：[1]新疆维吾尔自治区人民医院肾病科,乌鲁木齐830000 [2]新疆军区总医院肾病科,乌鲁木齐830000 [3]新疆医科大学第五附属医院肾病科,乌鲁木齐830000 [4]新疆喀什地区第二人民医院肾病科,新疆维吾尔自治区喀什市844000 [5]新疆伊犁州新华医院肾病科,新疆维吾尔自治区伊宁市835100 [6]新疆阿克苏地区第一人民医院肾病科,新疆维吾尔自治区阿克苏市843000

出　　处：《中华肾脏病杂志》2021年第6期490-498,共9页Chinese Journal of Nephrology

基　　金：国家自然科学基金(81560121);新疆维吾尔自治区自然科学基金(2018D01C132)。

摘　　要：目的探讨新疆维吾尔自治区肾活检病例肾脏疾病谱的构成和流行病学规律。方法收集1986年8月至2019年12月新疆维吾尔自治区12家医院肾活检病例的临床和病理资料,回顾性分析10684例肾活检病例疾病构成及病理类型分布特征。结果10684例肾活检病例中,男性5595例,女性5089例,汉族7804例(73.04%),维吾尔族2357例(22.06%),其他民族523例(4.90%)。10684例肾活检病例中原发性肾小球疾病、继发性肾小球疾病、肾小管间质病变、终末期肾病、遗传性和先天性疾病和移植后肾小球病变分别为8533例(79.87%)、1740例(16.29%)、229例(2.14%)、121例(1.13%)、46例(0.43%)和15例(0.14%),汉族、维吾尔族、其他民族(除汉族和维吾尔族以外的本地区其他民族)的肾脏疾病类型分布特点与总体肾脏疾病分布特点相同。汉族与维吾尔族间、汉族与其他民族间及维吾尔族与其他民族间疾病类型构成的差异无统计学意义(均P>0.05)。在8533例原发性肾小球疾病中,排名前5位的病理类型分别为IgA肾病[3095例(36.27%)]、系膜增生性肾小球肾炎[2008例(23.53%)]、膜性肾病[1503例(17.61%)]、肾小球微小病变[567例(6.64%)]和局灶性节段性肾小球硬化症[494例(5.79%)],其中汉族与维吾尔族间、汉族与其他民族间原发性肾小球疾病的前5种病理类型的差异均有统计学意义(均P<0.01),维吾尔族与其他民族原发性肾小球疾病的前5种病理类型的差异无统计学意义(P=0.113)。在1740例继发性肾小球疾病中,排名前5位的病理类型分别为狼疮肾炎[517例(29.71%)]、过敏性紫癜性肾炎[304例(17.47%)]、糖尿病肾小球硬化症[285例(16.38%)]、良性肾小动脉硬化症[196例(11.26%)]和系统性血管炎[101例(5.80%)]。汉族与维吾尔族之间、汉族与其他民族之间以及维吾尔族与其他民族之间继发性肾小球疾病的前5种病理类型分布特征不同。结论新疆维吾尔自治区原发性肾小球疾�Objective To investigate the composition of the renal disease spectrum and epidemiological characterisics for renal biopsy cases in Xinjiang Uygur Autonomous Region.Methods The clinical and pathological data of 10684 renal biopsy cases from 12 hospitals in Xinjiang Uygur Autonomous Region from August 1986 to December 2019 were collected and the composition of renal diseases and pathological types were analyzed retrospectively.Results Among the 10684 renal biopsy cases with 5595 males and 5089 females,7804 cases(73.04%)were Han nationality,2357 cases(22.06%)were Uygur nationality and 523 cases(4.90%)were other nationalities.Among the 10684 cases of renal biopsy,primary glomerular disease,secondary glomerular disease,tubulointerstitial disease,end-stage renal disease,genetic and congenital disease and post transplant glomerular disease were 8533 cases(79.87%),1740 cases(16.29%),229 cases(2.14%),121 cases(1.13%),46 cases(0.43%)and 15 cases(0.14%),respectively.The distribution of kidney diseases in Han,Uygur and other nationalities(except Han and Uygur in this region)was the same as that in general.There was no significant difference in disease type composition between Han and Uygur,Han and other nationalities,and Uygur and other nationalities(all P>0.05).Among the 8533 cases of primary glomerular diseases,the top five pathological types were IgA nephropathy(3095 cases,36.27%),mesangial proliferative glomerulonephritis(2008 cases,23.53%),membranous nephropathy(1503 cases,17.61%),minimal glomerulopathy(567 cases,6.64%)and focal segmental glomerulosclerosis(494 cases,5.79%).The top five pathological types of primary glomerular diseases were different between Han and Uygur,and Han and other nationalities(both P<0.01).There was no statistically significant difference between Uygur and other nationalities in the top five pathological types of primary glomerular diseases(P=0.113).Among 1740 cases of secondary glomerular diseases,the top five pathological types were lupus nephritis(517 cases,29.71%),Henoch-Sch?nlein purpura

关 键 词：活组织检查 流行病学 病理学 临床 IGA肾病 

分 类 号：R692[医药卫生—泌尿科学]