H型高血压心室重塑及构型特点相关性分析  

Correlation analysis of ventricular remodeling and configuration characteristics of H-type hypertension

作　　者：孙语 薛凌 SUN Yu;XUE Ling(Department of Cardiology,the Third Affiliated Hospital of Jinzhou Medical University,Jinzhou,Liaoning 121000,China)

机构地区：[1]锦州医科大学附属第三医院心内科,辽宁锦州121000

出　　处：《中国医学工程》2021年第6期7-10,共4页China Medical Engineering

基　　金：辽宁省自然科学基金项目(20170540372)。

摘　　要：目的通过超声心动图、血同型半胱氨酸(Hcy)水平等测算指标评价H型高血压患者与非H型高血压患者左心室结构变化情况及其与心室重构及构型特点的相关性。方法选取2018年10月至2020年6月锦州医科大学附属第三医院心内科确诊为原发性高血压住院患者148例,根据Hcy水平分成H型高血压组(HH组) 76例和非H型高血压组(NHH组)72例。完善心脏超声检查并计算左心室质量(LVM)、左心室质量指数(LVMI)、相对室壁厚度(RWT)、左心室重塑指数(LVRI),根据计算出数据将其分为4种几何构型,并比较差异。结果 HH组左心室重塑指数高于NHH组,差异有统计学意义(t=-2.306, P=0.023)。HH组向心性重构型所占比例(38.2%)多于NHH组(16.7%),差异有统计学意义(χ^(2)=8.526, P=0.005)。Hcy与LVMI及RWT直线相关性分析呈正相关(r=0.211, 0.223;P=0.010, 0.007)。结论 H型高血压较非H型高血压患者可能导致心室重塑进一步加重,且以向心性重构型多见。此外,高血压患者中Hcy水平与左心室构型相关。【Objective】To evaluate the left ventricular structural changes in patients with H-type hypertension and non-H-type hypertension by calculating the measurement indicators calculated by three-dimensional echocardiography,blood homocysteine(Hcy)levels and other related parameters.And to explore the correlation between Hcy level and ventricular remodeling and configuration characteristics in patients with essential hypertension.【Methods】A total of 148 inpatients who were diagnosed with essential hypertension in the cardiology department of our hospital from October 2018 to June 2020 were selected.After that,they were divided into H-type hypertension groups based on plasma Hcy levels(HH group,n=76)and non-H-type hypertension group(NHH group,n=72).After admission,the cardiac three-dimensional ultrasound measurement was completed and related indicators were calculated,including left ventricular mass(LVM),left ventricular mass index(LVMI),relative ventricular wall thickness(RWT),left ventricular remodeling index(LVRI).The selected candidates were divided into 4 geometric configurations based on the calculated data.Finally,relevant statistical methods were used to compare the differences between clinical indicators and measured parameters.【Results】The ventricular remodeling index in the H-type hypertension group was higher than that in the non-H-type hypertension group,and the difference was statistically significant(t=-2.306,P=0.023).The proportion of concentric remodeling in the HH group(38.2%)was more than that in the NHH group(16.7%),and the difference was statistically significant(χ^(2)=8.526,P=0.005).The Spearman method was used to analyze the linear correlation between Hcy and LVMI and RWT,and the results showed that Hcy was positively correlated with LVMI and RWT(r values were 0.211 and 0.223,respectively,P values were 0.010 and 0.007,respectively).【Conclusion】Compared with non-H-type hypertension patients,the degree of ventricular remodeling may be further aggravated in patients with H-type hyper

关 键 词：H型高血压 高同型半胱氨酸血症 左心室重塑 左心室构型 

分 类 号：R541.3[医药卫生—心血管疾病]