自拟补气养血清热方治疗胸腔镜下肺大疱切除术后非感染性发热临床疗效及对免疫功能、炎症反应和肺功能的影响  

Clinical Effect of Using Self-made Buqi Yangxu Qingre Recipe in the Treatment of Non-infectious Fever after Thoracoscopic Bullaectomy and Its Influnce on Immune Function, Inflammatory Reaction and Pulmonary Function

作　　者：赵亮 翟建宾 范子盼 于士昌 赵臣亮 李婵 ZHAO Liang;ZHAI Jianbin;FAN Zipan(Hebei Provincial Hospital of Traditional Chinese Medicine,Shijiazhuang Hebei 050000,China)

机构地区：[1]河北省中医院,河北石家庄050000

出　　处：《四川中医》2021年第5期91-96,共6页Journal of Sichuan of Traditional Chinese Medicine

基　　金：河北省2018年度中医药类科研计划课题(编号:2018006)。

摘　　要：目的:观察自拟补气养血清热方治疗胸腔镜下肺大疱切除术后非感染性发热临床疗效及对免疫功能、炎症反应和肺功能的影响。方法:将60例胸腔镜下肺大疱切除术后非感染性发热患者随机分为观察组(30例)和对照组(30例),对照组给予常规西医治疗干预,观察组在对照组基础上给予自拟补气养血清热方治疗,疗程为5d。比较2组干预的临床疗效。观察2组治疗前后中医症候积分、细胞免疫功能指标、炎性细胞因子、肺功能的变化。记录2组临床预后情况。结果:观察组临床疗效显著高于对照组,差异有统计学意义(94.00%vs 76.00%,P<0.05)。2组治疗后中医症候积分均较治疗前显著降低,差异有统计学意义(P<0.05),治疗后,观察组中医症候积分均低于对照组,差异有统计学意义(P<0.05)。2组治疗后CD3+、CD4+、CD4+/CD8+比值水平较治疗前显著升高,CD8+比值水平较治疗前显著降低,差异有统计学意义(P<0.05);治疗后,观察组CD8+水平低于对照组,其余指标均高于对照组,差异有统计学意义(P<0.05);2组治疗后血清IL-6、TNF-α水平较治疗前显著降低,IL-4、IL-10水平较治疗前显著升高,差异有统计学意义(P<0.05);治疗后,观察组IL-6、TNF-α水平低于对照组,IL-4、IL-10水平低于对照组,差异有统计学意义(P<0.05);2组治疗后MVV、FVC、FEV1、FEV1/FVC均较治疗前显著增加,差异有统计学意义(P<0.05);治疗后,观察组以上肺功能指标均高于对照组,差异有统计学意义(P<0.05)。观察组术后体温恢复时间、术后引流时间和术后住院时间均短于对照组,术后引流量、术后并发症发生率均少于对照组,差异有统计学意义(P<0.05)。结论:自拟补气养血清热方治疗胸腔镜下肺大疱切除术后非感染性发热临床疗效确定,不仅改善患者症状,还能改善患者免疫功能,抑制无菌性炎症反应,改善肺功能,缩短术后体温恢复时间和住院时间,降低术后并发�Objective: To observe the clinical effect of using Self-made Buqi Yangxue Qingre Recipe in the treatment of non-infectious fever after thoracoscopic bullaectomy and its influnce on immune function, inflammatory reaction and pulmonary function. Methods: 100 cases of non-infectious fever after thoracoscopic bullaectomy were randomly divided into an observation group(30 cases) and a controlled group(30 cases). The controlled group was given routine western medicine treatment intervention. The observation group was given Self-made Buqi Yangxue Recipe on the basis of the controlled group for 5 days. The clinical effects of the two groups were compared. The changes of TCM syndrome score, cellular immune function, inflammatory cytokines and lung function were observed before and after treatment in the two groups. The clinical prognosis of the two groups was recorded. Results: The clinical efficacy of the observation group was significantly higher than that of the controlled group(94.00% vs 76.00%, P < 0.05). After treatment, the scores of TCM symptoms in the observation group were significantly lower than those in the controlled group(P < 0.05), and the difference was statistically significant(P < 0.05). After treatment, the levels of CD3+, CD4+, CD4+/CD8+ in the two groups were significantly higher than those before treatment, and the levels of CD8+ in the observation group were significantly lower than those in the controlled group(P < 0.05);after treatment, the levels of CD8+ in the observation group were lower than those in the controlled group, and the other indicators were higher than those in the controlled group(P < 0.05). After treatment, the levels of IL-6 and TNF-alpha in the observation group were lower than those in the controlled group, and the levels of IL-4 and IL-10 were lower than those in the controlled group(P < 0.05);MVV, FVC, FEV1 and FEV1/FVC in the two groups were all significantly higher than those in the controlled group(P < 0.05);after treatment, the levels of IL-6 and TNF-alpha in the observa

关 键 词：补气养血清热方 胸腔镜 肺大疱切除术 非感染性发热 免疫功能 肺功能 炎症反应 

分 类 号：R563[医药卫生—呼吸系统]