免疫功能正常的人疱疹病毒6型脑膜脑炎一例  

A case of human herpes virus 6 meningoencephalitis with normal immune function

作　　者：赵玉[1] 王义义[1] 李倩[1] 李传侠 Zhao Yu;Wang Yiyi;Li Qian;Li Chuanxia(Department of Neurology,Tianjin Haihe Hospital,Tianjin 300350,China)

机构地区：[1]天津市海河医院神经内科,300350

出　　处：《中华神经科杂志》2021年第6期597-600,共4页Chinese Journal of Neurology

摘　　要：人疱疹病毒6型感染所致脑膜脑炎常见于获得性免疫缺陷综合征患者或移植术后患者,罕见于免疫正常成人。该病临床表现为头痛、嗜睡、昏迷、癫痫发作、精神症状和神经系统定位体征等,抗病毒治疗有效,治疗不及时则预后不良。文中总结分析了天津市海河医院2019年10月收治的1例人疱疹病毒6型感染所致脑膜脑炎患者的临床资料。患者反复发病,临床表现无特异性,不易诊断,脑脊液二代测序可提高其检测率。Meningoencephalitis caused by the human herpes virus 6 is common in acquired immune deficiency syndrome patients or in patients after organ transplantation,rarely in immunocompetent adults.The clinical manifestations include headache,drowsinesss,coma,epileptic attack,psychiatric symptom and focal neurological signs.Antiviral therapy is effective,however the prognosis should be poor if the treatment is not timely.The clinical data of one case of meningoencephalitis caused by the human herpes virus 6 in Tianjin Haihe Hospital in October 2019 were analyzed.Meningoencephalitis caused by the human herpes virus 6 can be recurrent.The clinical manifestations are nonspecific and the diagnosis is difficult.The next generation sequencing of cerebrospinal fluid is a powerful method to identify pathogens.

关 键 词：疱疹病毒6型 人 脑膜脑炎 脑脊髓液 二代测序 

分 类 号：R512.3[医药卫生—内科学]